A Prediction Tool for the Presence of Ceftriaxone-Resistant Uropathogens upon Hospital Admission

Antibiotics
Nancy Yanzhe LiJia En Wu

Abstract

Antimicrobial resistance among uropathogens is a particularly pressing problem in the Asia-Pacific region. The objectives of this study were to determine the incidence and susceptibility of uropathogens upon hospital admission and to develop a risk-scoring model to predict the presence of ceftriaxone-resistance uropathogens (CrP). This was a retrospective observational cohort study of patients with a positive urine culture within 48 h of presentation at National University Hospital, Singapore between June 2015 and August 2015. Escherichia coli was the most common uropathogen isolated (51.7%), followed by Klebsiella pneumonia (15.1%) and Pseudomonas aeruginosa (8.2%). Overall, 372 out of 869 isolates (42.8%) were resistant to ceftriaxone. Hospitalization for ≥2 days within past 30 days, antibiotic use within the past 3 months and male gender were associated with the presence of CrP. A risk score based on these parameters successfully predicted CrP with an area under the curve of 0.68. The risk score will help clinicians to accurately predict antibiotic resistance at the individual patient level and allow physicians to safely prescribe empiric ceftriaxone in patients at low risk of CrP, thus reducing the antibiotic selection pres...Continue Reading

References

Apr 6, 2000·The American Journal of Emergency Medicine·S W WrightD W Haas
Jul 13, 2002·The American Journal of Medicine·Betsy Foxman
Feb 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kalpana GuptaUNKNOWN European Society for Microbiology and Infectious Diseases
Sep 4, 2015·Nature Reviews. Urology·Hosam M ZowawiDavid L Paterson
Jun 18, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emily WalkerElizabeth B Hirsch
Jan 3, 2018·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hyun-Sop ChoeUNKNOWN GPIU Asian Investigators

❮ Previous
Next ❯

Citations

Sep 4, 2020·Current Opinion in Urology·Ekaterina Kulchavenya

❮ Previous
Next ❯

Software Mentioned

CHAID

Related Concepts

Related Feeds

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Related Papers

JAMA : the Journal of the American Medical Association
I R Daniels, S R Zaman
Eastern Mediterranean Health Journal = La Revue De Santé De La Méditerranée Orientale = Al-Majallah Al-ṣiḥḥīyah Li-sharq Al-mutawassiṭ
Hamed AkhavizadeganSamaneh Akbarpour
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Pranita D TammaAaron M Milstone
© 2022 Meta ULC. All rights reserved