A predictive focus of gain modulation encodes target trajectories in insect vision

Steven D WiedermanDavid C O'Carroll


When a human catches a ball, they estimate future target location based on the current trajectory. How animals, small and large, encode such predictive processes at the single neuron level is unknown. Here we describe small target-selective neurons in predatory dragonflies that exhibit localized enhanced sensitivity for targets displaced to new locations just ahead of the prior path, with suppression elsewhere in the surround. This focused region of gain modulation is driven by predictive mechanisms, with the direction tuning shifting selectively to match the target's prior path. It involves a large local increase in contrast gain which spreads forward after a delay (e.g. an occlusion) and can even transfer between brain hemispheres, predicting trajectories moved towards the visual midline from the other eye. The tractable nature of dragonflies for physiological experiments makes this a useful model for studying the neuronal mechanisms underlying the brain's remarkable ability to anticipate moving stimuli.


Dec 5, 1978·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·G A Horridge
Oct 26, 1995·Nature·S N Watamaniuk, S P McKee
Apr 7, 1999·Nature·M J BerryM Meister
Jul 15, 2000·Neuron·J H ReynoldsR Desimone
Mar 31, 2005·Vision Research·Franco Pestilli, Marisa Carrasco
Nov 14, 2006·The Journal of Comparative Neurology·Jun-Ya Okamura, Nicholas J Strausfeld
Mar 17, 2007·Current Biology : CB·Paul D BarnettDavid C O'carroll
Apr 24, 2007·Nature Neuroscience·Greg SchwartzMichael J Berry
Jun 23, 2009·Trends in Neurosciences·Karin Nordström, David C O'Carroll
Nov 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Douglas M BolzonDavid C O'Carroll
Jun 12, 2010·Journal of Neurophysiology·Joonyeol Lee, John H R Maunsell
Jan 29, 2011·Biology Letters·Karin NordströmDavid C O'Carroll
Apr 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shreesh P MysoreEric I Knudsen
May 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steven D Wiederman, David C O'Carroll
Nov 1, 2012·Frontiers in Neural Circuits·James R DunbierDavid C O'Carroll
Dec 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Paloma T Gonzalez-BellidoRobert M Olberg
Dec 25, 2012·Current Biology : CB·Steven D Wiederman, David C O'Carroll
Mar 12, 2013·Nature Neuroscience·Shreesh P Mysore, Eric I Knudsen
Aug 9, 2013·Nature·Shin-ya TakemuraDmitri B Chklovskii
Aug 9, 2013·Nature·Matthew S MaisakAlexander Borst
Aug 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steven D WiedermanDavid C O'Carroll
Nov 21, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric Y ChenMichael J Berry
Dec 10, 2014·Nature·Matteo MischiatiAnthony Leonardo
May 15, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jacob W AptekarMark A Frye
Feb 14, 2017·Current Biology : CB·Mehmet F Keleş, Mark A Frye

❮ Previous
Next ❯


Dec 1, 2017·The Journal of Experimental Biology·Elisa RigosiDavid C O'Carroll
Oct 19, 2019·The Journal of Comparative Neurology·Joss von HadelnUwe Homberg
Apr 20, 2018·Frontiers in Neural Circuits·Jessica R KohnRudy Behnia
Jun 2, 2020·Frontiers in Computational Neuroscience·Frances S ChanceFelix Wang
Aug 10, 2019·The Journal of Experimental Biology·Joseph M FabianSteven D Wiederman
Aug 26, 2020·Current Opinion in Insect Science·Benjamin Horatio LancerSteven D Wiederman
Feb 19, 2021·Scientific Reports·Joseph M Fabian, Steven D Wiederman
Feb 26, 2020·Current Biology : CB·Vivek Nityananda
Aug 14, 2019·Current Opinion in Physiology·Eiman Azim, Kazuhiko Seki
Jun 10, 2020·Current Biology : CB·Andrew M HeinGraham K Taylor
Jan 9, 2021·Biochemical and Biophysical Research Communications·Alex M WinsorElizabeth M Jakob

❮ Previous
Next ❯

Methods Mentioned

fluorescence imaging

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

Current Biology : CB
Steven D Wiederman, David C O'Carroll
The Journal of Experimental Biology
Bart R H GeurtenDavid C O'Carroll
Proceedings of the National Academy of Sciences of the United States of America
Paloma T Gonzalez-BellidoRobert M Olberg
PM & R : the Journal of Injury, Function, and Rehabilitation
Thomas E Stautzenbach
Asian Cardiovascular & Thoracic Annals
Vinitha V Nair, Jayakumar Thanathu Krishnan Nair
© 2021 Meta ULC. All rights reserved