A Predictive Model for Nodal Metastases in Patients With Appendiceal Cancers.

Annals of Surgery
Ryan W DayNabil Wasif

Abstract

Histologic subtypes of appendiceal cancer vary in their propensity for metastases to regional lymph nodes (LN). A predictive model would help direct subsequent surgical therapy. The National Cancer Database was queried for patients with appendiceal cancer undergoing surgery between 1998 and 2012. Multivariable logistic regression was used to develop a predictive model of LN metastases which was internally validated using Brier score and Area under the Curve (AUC). A total of 21,647 patients were identified, of whom 9079 (41.9%) had node negative disease, 4575 (21.1%) node positive disease, and 7993 (36.9%) unknown LN status. The strongest predictors of LN positivity were histology (carcinoid tumors OR 12.78, 95% CI 9.01-18.12), increasing T Stage (T3 OR 3.36, 95% CI 2.52-4.50, T4 OR 6.30, 95% CI 4.71-8.42), and tumor grade (G3 OR 5.55, 95% CI 4.78-6.45, G4 OR 5.98, 95% CI 4.30-8.31). The coefficients from the regression analysis were used to construct a calculator that generated predicted probabilities of LN metastases given certain inputs. Internal validation of the overall model showed an AUC of 0.75 (95% CI 0.74-0.76) and Brier score of 0.188. Histology-specific predictive models were also constructed with an AUC that varied...Continue Reading

References

Feb 6, 2003·Cancer·Irvin M ModlinMark Kidd
Apr 19, 2006·Archives of Surgery·Zubin M Bamboat, David L Berger
Oct 12, 2010·Journal of Endocrinological Investigation·K I AlexandrakiG A Kaltsas
Jul 13, 2011·Annals of Surgical Oncology·Hatem El HalabiArmando Sardi
Feb 4, 2012·Annals of Surgical Oncology·Kiran K TuragaT Clark Gamblin
Apr 21, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C G WhitfieldJ P Garner
Jul 7, 2012·Journal of Surgical Oncology·Cary HsuJanice N Cormier
Jan 7, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Schelomo MarmorBeth A Virnig
Jan 6, 2016·Neuroendocrinology·U-F PapeUNKNOWN Vienna Consensus Conference participants
Feb 28, 2017·JAMA Oncology·Daniel J BoffaDavid P Winchester
Sep 21, 2018·Neuroendocrinology·Christos ToumpanakisUNKNOWN ENETS 2016 Munich Advisory Board Participants

❮ Previous
Next ❯

Citations

Jan 15, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Dan WangYuqiang Li
Apr 30, 2020·Journal of Surgical Oncology·Adrienne B ShannonGiorgos C Karakousis
Jul 14, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hiroshi TakeyamaUNKNOWN study group of appendiceal neoplasms in Japan Society of Colorectal Cancer Research Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.