A Predictive Model for Temporal Artery Biopsy in the Setting of Suspected Giant Cell Arteritis: A Validation Study.

Ophthalmic Plastic and Reconstructive Surgery
Ezekiel WeisKelsey A Roelofs

Abstract

A previously published predictive model based on threshold parameters for erythrocyte sedimentation rate, c-reactive protein, and platelet count demonstrated that 40% of patients who underwent biopsy may not have required it. The current study was performed to evaluate the model's performance on an independent data set. This is a retrospective consecutive series of patients undergoing temporal artery biopsy (TAB) in a single health region in Canada. The model was applied to a multicenter cohort of patients undergoing TAB by a variety of surgical services. A centralized pathological database serving multiple institutions and surgical services was used to identify patients undergoing TAB. Over a 7-year period, patients undergoing TAB were identified via a central pathological database. Those who had concurrent illnesses which would likely affect erythrocyte sedimentation rate, c-reactive protein, and platelet count, patients on steroids for >2 weeks by the time of biopsy, and those with missing serum markers were excluded. The previously developed model was applied to the 222 patients enrolled. The model correctly identified 29% of patients with a pretest probability of 0% for a positive biopsy and 9% with a pretest probability o...Continue Reading

References

Apr 1, 1979·Scottish Medical Journal·F JonassonR A Elton
Mar 1, 1988·Neurology·R J CaselliJ P Whisnant
Aug 1, 1986·Archives of Ophthalmology·M L Slavin
Jan 24, 1986·JAMA : the Journal of the American Medical Association·J Säve-SöderberghB A Bengtsson
Nov 1, 1984·Mayo Clinic Proceedings·S Hall, G G Hunder
Apr 1, 1993·Ophthalmology·P D AielloG G Hunder
Oct 15, 2003·Arthritis and Rheumatism·Anne ProvenGene G Hunder
May 10, 2005·Ophthalmology·Ryan D Niederkohr, Leonard A Levin
Nov 17, 2005·QJM : Monthly Journal of the Association of Physicians·J LentonJ R Nash
May 16, 2006·Annals of the Rheumatic Diseases·A MahrL Guillevin
Apr 17, 2007·Medicine·Miguel A Gonzalez-GayJavier Llorca
Jan 1, 2008·Arthritis and Rheumatism·Reva C LawrenceUNKNOWN National Arthritis Data Workgroup
Sep 3, 2010·Current Opinion in Ophthalmology·Nilufer Kale, Eric Eggenberger
Jun 28, 2011·The British Journal of Surgery·E YpsilantisR Y Ball
Apr 19, 2013·The Permanente Journal·Michael Alberts
May 2, 2014·Annals of the Royal College of Surgeons of England·A R Gunawardene, H Chant
Jul 5, 2017·The Journal of the Royal College of Physicians of Edinburgh·S GajreeB Dhillon
Sep 8, 2017·American Journal of Surgery·Marios PapadakisGunnar Hübner
Dec 9, 2017·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Ezekiel WeisSteven Gilberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Kevin L RieckKenneth J Warrington
QJM : Monthly Journal of the Association of Physicians
J LentonJ R Nash
© 2021 Meta ULC. All rights reserved