A predictive model for treatment response in patients with locally advanced esophageal squamous cell carcinoma after concurrent chemoradiotherapy: based on SUVmean and NLR

BMC Cancer
Chunsheng WangMinghuan Li

Abstract

We conducted this study to combine the mean standardized uptake value (SUVmean) and neutrophil to lymphocyte ratio (NLR) to establish a strong predictive model for patients with esophageal squamous cell carcinoma (ESCC) after concurrent chemoradiotherapy (CCRT). We retrospectively analyzed 163 newly diagnosed ESCC patients treated with CCRT. Eighty patients (training set) were randomly selected to generate cut-off SUVmean and NLR values by receiver operating characteristic (ROC) curve analysis and to establish a predictive model by using the independent predictors of treatment outcomes. Then, we evaluated the performance of the prediction model regarding treatment outcomes in the testing set (n = 83) and in all sets. A high SUVmean (> 5.81) and high NLR (> 2.42) at diagnosis were associated with unfavorable treatment outcomes in patients with ESCC. The prediction model had a better performance than the simple parameters (p < 0.05). With a cut-off value of 0.77, the prediction model significantly improved the specificity and positive predictive value for treatment response (88.9 and 92.1% in the training set, 95.8 and 97.1% in the testing set, and 92.2 and 91.8% in all sets, respectively). The pretreatment SUVmean and NLR were i...Continue Reading

References

Sep 24, 2004·The Cancer Journal·Jeffrey T YapDavid W Townsend
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Sep 9, 2008·Cell·Peggy P Hsu, David M Sabatini
Sep 8, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Q-Q LiH-X Lin
Jan 8, 2010·World Journal of Surgical Oncology·Farhan RashidSyed Y Iftikhar
Sep 3, 2010·Contrast Media & Molecular Imaging·S Del VecchioM Salvatore
Feb 1, 2011·International Journal of Radiation Oncology, Biology, Physics·Kristin A HigginsDavid M Brizel
Jun 20, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Farhad AzimiJohn F Thompson
Sep 25, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G C ParkS Y Kim
Oct 25, 2013·Nature Reviews. Cancer·Eran ElinavRichard A Flavell
Jun 6, 2014·Journal of Immunology Research·Glauben LandskronMarcela A Hermoso
Jun 28, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Eun Jin YooYong Chan Lee
Nov 28, 2017·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S T McSorleyD C McMillan
Feb 27, 2018·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Ryoichi MiyamotoMasayoshi Yamamoto
Mar 27, 2019·Asian Pacific Journal of Cancer Prevention : APJCP·I Putu Yuda PrabawaIda Bagus Amertha Putra Manuaba

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

MedCalc
Xeleris
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.