A Predictive Model of High Shear Thrombus Growth

Annals of Biomedical Engineering
Marmar MehrabadiDavid N Ku

Abstract

The ability to predict the timescale of thrombotic occlusion in stenotic vessels may improve patient risk assessment for thrombotic events. In blood contacting devices, thrombosis predictions can lead to improved designs to minimize thrombotic risks. We have developed and validated a model of high shear thrombosis based on empirical correlations between thrombus growth and shear rate. A mathematical model was developed to predict the growth of thrombus based on the hemodynamic shear rate. The model predicts thrombus deposition based on initial geometric and fluid mechanic conditions, which are updated throughout the simulation to reflect the changing lumen dimensions. The model was validated by comparing predictions against actual thrombus growth in six separate in vitro experiments: stenotic glass capillary tubes (diameter = 345 µm) at three shear rates, the PFA-100(®) system, two microfluidic channel dimensions (heights = 300 and 82 µm), and a stenotic aortic graft (diameter = 5.5 mm). Comparison of the predicted occlusion times to experimental results shows excellent agreement. The model is also applied to a clinical angiography image to illustrate the time course of thrombosis in a stenotic carotid artery after plaque cap r...Continue Reading

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Citations

Dec 29, 2016·Annals of Biomedical Engineering·P García CarrascalF J Manuel Martín
May 26, 2017·Biotechnology and Bioengineering·Hamid Hosseinzadegan, Danesh K Tafti
Feb 22, 2017·Scientific Reports·Wei-Tao WuJames F Antaki
Oct 3, 2019·Journal of the Royal Society, Interface·B J M van RooijA G Hoekstra
Jul 23, 2020·Blood Advances·Dongjune A KimDavid N Ku
Nov 27, 2019·APL Bioengineering·Dongjune KimDavid N Ku
May 5, 2017·Cardiovascular Engineering and Technology·Hamid Hosseinzadegan, Danesh K Tafti
Apr 26, 2017·Annual Review of Biomedical Engineering·Lauren D C Casa, David N Ku
Oct 31, 2020·Scientific Reports·Britt J M van RooijDavid N Ku
Mar 2, 2021·Frontiers in Bioengineering and Biotechnology·Julien LemétayerLisa Prahl Wittberg
May 10, 2018·Biophysical Journal·Erik J CarboniAnson W K Ma
Apr 13, 2021·Journal of Biomechanics·Mansur ZhussupbekovJames F Antaki

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