A predictive model of varicella-zoster virus infection after autologous peripheral blood progenitor cell transplantation

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
M OffidaniP Leoni

Abstract

Varicella-zoster virus (VZV) frequently causes severe infections in patients who have undergone bone marrow transplantation. The frequency of, characteristics of, and risk factors for this infection were studied in 164 patients undergoing autologous peripheral blood progenitor cell transplantation (PBPCT). Twenty-six patients (15.8%) developed VZV infection, and the actuarial risk was 10% at 1 year. No patient had visceral dissemination or died because of VZV, although one-third of the patients developed postherpetic neuralgia. By multivariate analysis, a CD4(+) lymphocyte count of <200 cells/microL (P<.0001; odds ratio [OR], 2.0) and a CD8(+) lymphocyte count of <800 cells/microL (P=.0073; OR, 2.0) at day 30 after transplantation were factors associated with VZV infection. Patients with both these adverse factors had an actuarial risk of VZV of 48% at 1 year. Patients with deficiency in both CD4(+) and CD8(+) lymphocytes are at high risk of VZV infection. These patients should be considered as candidates for preventive therapy, but whether for antiviral therapy or vaccination remains to be investigated.

References

May 1, 1990·Journal of Neuroscience Research·C Sadzot-DelvauxB Rentier
May 1, 1986·The Journal of Infectious Diseases·P LjungmanB Wahren
Dec 1, 1985·The Journal of Infectious Diseases·R M LocksleyJ D Meyers
Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
Jan 1, 1995·Human Heredity·R S HoulstonN E Morton
Jul 4, 1996·The New England Journal of Medicine·R G Kost, S E Straus
Oct 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F A ManianK H Fulling
Dec 12, 1997·The Journal of Infectious Diseases·A A GershonS Bakshi
Oct 3, 1998·Annals of Internal Medicine·E J AnaissieM J Keating
Dec 16, 1998·The Journal of Infectious Diseases·P AnnunziatoS Silverstein
Jun 15, 1999·Virology·P G KennedyJ W Gow
Mar 9, 2000·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Y KocD R Snydman
Feb 1, 1957·A.M.A. Archives of Dermatology·J M DE MORAGAS, R R KIERLAND

❮ Previous
Next ❯

Citations

Mar 15, 2006·Annals of Hematology·Stefan Neuburger, Georg Maschmeyer
May 22, 2013·Archives of Dermatological Research·Qian XingFuqiang Chen
Nov 15, 2002·The New England Journal of Medicine·Masahiro KamiYoichi Takaue
Sep 9, 2008·The Pediatric Infectious Disease Journal·Coleman J BryanMasako Shimamura
Aug 18, 2005·European Journal of Haematology·Khalid Ahmed Al-AnaziDavid Alan Price Evans
May 28, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J E RogersM Craig
Aug 11, 2004·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·David M WeinstockKent A Sepkowitz
Jun 23, 2006·Reviews in Medical Virology·Mark Quinlivan, Judith Breuer
Sep 17, 2011·Expert Review of Vaccines·Mark QuinlivanD Scott Schmid
Sep 13, 2003·Blood·Bart BarlogieJohn Crowley
Mar 28, 2020·The Tohoku Journal of Experimental Medicine·Kenji MurataShouichi Ohga
Jul 10, 2019·JAMA : the Journal of the American Medical Association·Adriana BastidasUNKNOWN ZOE-HSCT Study Group Collaborators
Jan 22, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ji-Man KangYae-Jean Kim
May 19, 2021·Clinical Medicine : Journal of the Royal College of Physicians of London·Amy E EdwardsJonathan Lambourne
Jul 1, 2021·Human Vaccines & Immunotherapeutics·Alemnew F DagnewAnne E Schuind

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.