A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS,S Malaria Vaccine Evaluation Group

The New England Journal of Medicine
J A StouteM Marchand

Abstract

The candidate vaccines against malaria are poorly immunogenic and thus have been ineffective in preventing infection. We developed a vaccine based on the circumsporozoite protein of Plasmodium falciparum that incorporates adjuvants selected to enhance the immune response. The antigen consists of a hybrid in which the circumsporozoite protein fused to hepatitis B surface antigen (HBsAg) is expressed together with unfused HBsAg. We evaluated three formulations of this antigen in an unblinded trial in 46 subjects who had never been exposed to malaria. Two of the vaccine formulations were highly immunogenic. Four subjects had adverse systemic reactions that may have resulted from the intensity of the immune response after the second dose, which led us to reduce the third dose. Twenty-two vaccinated subjects and six unimmunized controls underwent a challenge consisting of bites from mosquitoes infected with P. falciparum. Malaria developed in all six control subjects, seven of eight subjects who received vaccine 1, and five of seven subjects who received vaccine 2. In contrast, only one of seven subjects who received vaccine 3 became infected (relative risk of infection, 0.14; 95 percent confidence interval, 0.02 to 0.88; P<0.005). ...Continue Reading

References

Jan 1, 1989·Advances in Immunology·V Nussenzweig, R S Nussenzweig
Jan 1, 1986·The American Journal of Tropical Medicine and Hygiene·J D ChulayW T Hockmeyer
Jan 1, 1974·Transactions of the Royal Society of Tropical Medicine and Hygiene·K H RieckmannK W Sell
Jul 1, 1982·The Journal of Experimental Medicine·E H NardinY Chomcharn
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·L F Scheller, A F Azad
Jan 1, 1994·Annual Review of Immunology·P Matzinger
Aug 1, 1993·The American Journal of Tropical Medicine and Hygiene·J E EganD M Gordon
May 1, 1996·The Journal of Experimental Medicine·F Di Rosa, P Matzinger

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Citations

Oct 10, 2001·European Journal of Immunology·M DupuisG Ott
Jan 1, 1997·Springer Seminars in Immunopathology·R C HedstromS L Hoffman
Jun 22, 1999·Immunologic Research·E R Brandt, M F Good
Aug 1, 2000·Indian Journal of Clinical Biochemistry : IJCB·S KurellaD N Rao
Nov 30, 2006·Wiener klinische Wochenschrift·Nicole WesterfeldRinaldo Zurbriggen
May 21, 2011·Clinical Reviews in Allergy & Immunology·Christopher Chang
Apr 17, 2004·Journal of Immunological Methods·Gary R MatyasCarl R Alving
Nov 18, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Pramatha R BhattacharyaC R Pillai
Jan 8, 1999·Acta Tropica·F G AbathY M Gomes
Nov 19, 2002·International Journal for Parasitology·Sócrates HerreraMyriam Arévalo-Herrera
Nov 18, 1997·International Journal for Parasitology·W Trager, J B Jensen
Mar 21, 1998·International Journal for Parasitology·F E Cox
Nov 27, 1999·International Journal for Parasitology·D C de GraafA Bonnin
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·P R Bhattacharya
Dec 24, 1997·Lancet·D Kwiatkowski, K Marsh
Jun 24, 2003·Comparative Immunology, Microbiology and Infectious Diseases·Claude Leclerc
Dec 14, 2001·Molecular Immunology·M Arévalo-Herrera, S Herrera
Mar 2, 1999·Pharmacology & Therapeutics·G F MabezaG Weiss
May 14, 2003·Molecular and Biochemical Parasitology·Evelina AngovJeffrey A Lyon
Sep 25, 1998·Molecular and Biochemical Parasitology·W R PyperA Saul
Mar 4, 2000·Molecular and Biochemical Parasitology·A AllouecheB M Greenwood
Feb 28, 2001·Nature Biotechnology
Apr 27, 2001·Trends in Parasitology·J D KurtisP E Duffy
May 1, 1997·Parasitology Today·D L Doolan, S L Hoffman
Aug 1, 1997·Parasitology Today·S C Gilbert, A V Hill
Oct 17, 2006·Parasitology Today·H D Engers, T Godal
Oct 17, 2006·Parasitology Today·D E ArnotW Kilama
May 11, 1999·Parasitology Today·P L Alonso, M Dgedge
Aug 3, 2001·Vaccine·P MoingeonA Lindberg
Nov 22, 2002·Vaccine·Wania Renata SantosClarisa Beatriz Palatnik de Sousa

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