Abstract
By occluding the fourth ventricle simultaneously obtaining telemetric data on intracranial pressure (ICP) and cerebrospinal fluid (CSF) production, the authors of this study investigate a variety of physiologic parameters in cases of experimental hydrocephalus. The aim of this study is to provide a new context on the disrupted homeostasis in hydrocephalus and guide toward improved treatment based on multiple physiological parameters. Hydrocephalus was induced in ten 21-day-old Sprague-Dawley rats by blocking the flow of CSF to the fourth ventricle with kaolin. Ten days post induction, when physical signs of ventriculomegaly reached Evan's ratio (ER) of ≥0.46, CSF flow and ICP were measured while manipulating body position (0°, 45°, 90°) and heart rate. In hydrocephalic animals (ER ≥0.46), we found a near-steady average acute ICP (13.638 ± 2.331) compared to age-matched controls (ER <0.30) (13.068 ± 8.781), whose ICP fluctuated with the position. Hydrocephalic and controls exhibited an insignificant degree of parabolic shifts in CSF production when body position was changed from prone to 90° and again when moved back to the prone position, a trend more noteworthy in controls (P = 0.1322 and 0.2772). A Pearson's Correlation found...Continue Reading
References
Jun 1, 1976·The American Journal of Physiology·J A Krasney, R C Koehler
Dec 31, 1997·Physical Therapy·S BrimioulleR J Kahn
Apr 28, 2006·Neurosurgery·Maria A PocaEva Corral
Feb 29, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G NagraM Johnston
Oct 14, 2014·Acta neurochirurgica·Morten AndresenMarianne Juhler
Jan 3, 2015·Journal of Neuroscience Methods·Jason K KarimyJ Marc Simard
Feb 13, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steffi Dreha-KulaczewskiJens Frahm
Mar 10, 2015·Journal of Neurosurgery. Pediatrics·Dustin K RaganDavid D Limbrick
May 21, 2016·Journal of Neurosurgery. Pediatrics·Pranav VenkataramanBarry R Lutz
May 25, 2016·Neurocritical Care·Anneli ThelanderssonÅsa Cider
Mar 28, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M UldallR H Jensen
Jun 26, 2017·Acta neurochirurgica·Marek Czosnyka, Zofia H Czosnyka
Feb 24, 2018·Frontiers in Physiology·Eric A SchmidtJean M Senard
Jun 11, 2020·Fluids and Barriers of the CNS·Sajedeh EftekhariRigmor H Jensen