Abstract
Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice for high-risk hematological malignancies, yet a major complication associated with this therapy is acute graft-versus-host disease (GVHD). Despite a well-defined pathophysiological mechanism, there are no definitive markers for predicting acute GVHD development or progression to advanced stages. In the current study, we enrolled four acute GVHD and four acute GVHD-free recipients of allogeneic HSCT and collected peripheral blood just prior to onset of clinical acute GVHD for analysis on Affymetrix GeneChip Human Genome U133 Plus 2.0 microarrays. We noted significant differences in expression of 1,658 genes between control and acute GVHD patients, based on an analysis of covariance (ANCOVA) by type of transplant, a pooled error estimate, and a false discovery rate (FDR) of 10%. In conclusion, we offer the first report of a preliminary molecular signature of acute GVHD in allogeneic HSCT patients.
References
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T WerfelJ Zwirner
Apr 21, 2001·Blood·C SchmaltzM R van den Brink
May 11, 2002·Nature Reviews. Immunology·Marcel R M van den Brink, Steven J Burakoff
Nov 9, 2002·Blood·Cornelius SchmaltzMarcel R M van den Brink
Feb 14, 2003·Bioinformatics·Anat ReinerYoav Benjamini
Mar 29, 2003·Blood·Tamotsu IchibaJames L M Ferrara
Oct 15, 2003·Blood Reviews·Pavan Reddy, James L M Ferrara
Feb 14, 2004·Blood·Vijay ReddyJohn R Wingard
Apr 2, 2004·Immunology·Ralf GutzmerThomas Werfel
May 27, 2004·The American Journal of Pathology·Philip B SugermanMarcel R M van den Brink
Nov 19, 2004·Physiological Genomics·Robert J FeezorUNKNOWN Inflammation and Host Response to Injury, Large-Scale Collaborative Research Program
Jan 15, 2005·Cell Transplantation·Tobias BergZhiguang Guo
Jun 3, 2005·Clinical Medicine & Research·Tsuyoshi Iwasaki
Mar 16, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephan BrandJulia Dambacher
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Motomu ShimizuTakayuki Yoshimoto
Aug 15, 2006·Nature Immunology·Jason S StumhoferChristopher A Hunter
Aug 19, 2006·The Journal of Investigative Dermatology·Lixin ZhouAnita C Gilliam
Dec 21, 2006·Microbiology and Immunology·Seiho NagafuchiNobuyoshi Shimizu
Dec 26, 2006·Nature·Yan ZhengWenjun Ouyang
Mar 24, 2007·PLoS Medicine·Chantal BaronClaude Perreault
Sep 1, 2007·Experimental Hematology·Matthew P BuzzeoVijay Reddy
Sep 1, 2004·Cell Transplantation·Tobias BergZhiguang Guo
Citations
Jun 21, 2011·DNA and Cell Biology·Peilong LaiXin Du
May 16, 2012·Blood·Christian HarkenseeUNKNOWN Japan Marrow Donor Program
Dec 17, 2009·BMC Bioinformatics·Jun WuYajun Yi
Feb 10, 2011·PloS One·Peter NovotaRalf Dressel
Apr 12, 2012·Haematologica·Maria CuzzolaFortunato Morabito
Mar 25, 2014·BMC Hematology·Dmitry N GrigoryevShui Q Ye
May 22, 2009·Expert Opinion on Biological Therapy·Matthew D ScaifeJ A Medin
Jul 10, 2012·Experimental Hematology·Jan VernerSarka Pospisilova
May 31, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S EhnertA K Nussler
Apr 15, 2011·Immunological Reviews·Maria-Grazia RoncaroloRosa Bacchetta
Mar 4, 2014·Stem Cells·Malte von Bonin, Martin Bornhäuser
Oct 30, 2014·Journal of Cellular and Molecular Medicine·Christopher OelkrugStephan Fricke
Jul 1, 2010·Cell Transplantation·Jeoung Eun LeeDong Ryul Lee
Nov 9, 2010·Cell Transplantation·David J EvePaul R Sanberg
Jun 15, 2017·Pediatric Transplantation·Britt GustafssonBritt-Marie Frost
Feb 8, 2011·Cell Transplantation·S EhnertA K Nüssler
Apr 20, 2017·Frontiers in Immunology·Rihab GamRalf Dressel
Mar 3, 2020·Frontiers in Immunology·Kati HyvärinenJarmo Ritari
Aug 21, 2020·Blood Advances·Eleonora LatisLars Rogge