PMID: 8609517Mar 1, 1996Paper

A preliminary study into the sensitivity of disease activity detection by serial weekly magnetic resonance imaging in multiple sclerosis

Journal of Neurology, Neurosurgery, and Psychiatry
M LaiD H Miller

Abstract

Long TR and gadolinium enhanced spin echo brain MRI was performed weekly for three months in three patients with relapsing-remitting or secondary progressive multiple sclerosis. During the study, 38 new enhancing lesions were seen; 11 showed enhancement for less than four weeks, and two enhanced on only one scan. All 16 new lesions seen on long TR scans showed initial enhancement. When only every fourth (monthly) scan was analysed, a total of 33 new enhancing lesions were seen. Subject to confirmation in a larger cohort, the results suggest: (a) that blood brain barrier leakage is an invariable event in new lesion development in relapsing-remitting and secondary progressive multiple sclerosis; (b) the small increase in sensitivity of weekly scanning does not justify its use in preference to monthly scanning when monitoring treatments.

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Citations

May 17, 2005·Physical Medicine and Rehabilitation Clinics of North America·Jack H Simon
Sep 19, 1998·Journal of the Neurological Sciences·M FilippiG Comi
Jul 20, 2002·Clinical Neurology and Neurosurgery·David H Miller
May 4, 2011·Nature Reviews. Neurology·Maria Trojano
Jun 11, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·O CiccarelliC Pozzilli
Apr 7, 2007·Topics in Magnetic Resonance Imaging : TMRI·Yulin Ge
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D H Miller, A J Thompson
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·David H Miller
May 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Rohit BakshiJerry S Wolinsky
Jul 10, 2003·Lancet Neurology·Gianvito MartinoMassimo Filippi
Dec 11, 2008·Neuroimaging Clinics of North America·Anthony Traboulsee, David K B Li
Jul 29, 2006·Magnetic Resonance Imaging Clinics of North America·Jack H Simon
Nov 22, 2005·Radiologic Clinics of North America·Jack H Simon
Dec 17, 2009·Acta Neurologica Scandinavica·M A SahraianL Kappos
Dec 15, 2010·PloS One·Carlos RiverosUNKNOWN ANZgene Multiple Sclerosis Genetics Consortium
Jan 18, 2006·Clinical Neurology and Neurosurgery·Christian Confavreux, Sandra Vukusic
Nov 29, 2001·Journal of Molecular Biology·M G RudolphI A Wilson
Sep 13, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Charles Rg GuttmannFrançois Cotton
Feb 13, 1999·Multiple Sclerosis : Clinical and Laboratory Research·M FilippiD H Miller
Nov 7, 2000·Multiple Sclerosis : Clinical and Laboratory Research·M Filippi
Apr 25, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H HegenT Berger
Mar 31, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Henrik Kahr MathiesenLars G Hanson
Oct 13, 2005·Brain : a Journal of Neurology·K T M FernandoD H Miller
Sep 8, 2006·Journal of Neuropathology and Experimental Neurology·Sonja HochmeisterHans Lassmann
Feb 26, 2003·Neurology·Francois CottonCharles R G Guttmann

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