PMID: 3751519Jun 1, 1986Paper

A preliminary study of corneal penetration of 125I-labelled idoxuridine liposome

Acta Ophthalmologica
S K DharmaG A Peyman

Abstract

We compared corneal penetration of idoxuridine (IDU) to liposome-encapsulated IDU. Liposomes of phosphatidic acid, phosphatidyl choline, and alpha-tocopherol in a molar ratio 1:8:1 were prepared using the reverse phase evaporation method. New Zealand albino rabbits received either 0.1% solution of I125-labelled aqueous IDU or liposome-encapsulated IDU topically every 2 min for 6 min. Corneal, aqueous, and vitreous samples were assayed for I125 radioactivity at 15 min and at 1, 2, 3, and 6 h following drug application. Our results indicated that corneal penetration of liposomal IDU was significantly increased over the regular form of the drug for a time interval of 6 h.

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Citations

May 1, 1996·Journal of Microencapsulation·J Al-MuhammedA A Hincal
Aug 1, 1996·The Journal of Pharmacy and Pharmacology·H H LinY H Tsai
Jul 9, 2009·Retina·Gholam A PeymanDarius M Moshfeghi
Aug 18, 2009·Acta Ophthalmologica·Fawzia S HabibDina Fathalla
Mar 5, 2013·Artificial Cells, Nanomedicine, and Biotechnology·Lalit KumarBhuvaneshwar Vaidya
Jan 1, 1993·Journal of Microencapsulation·M SinghM Mezei
Apr 1, 1996·Pharmaceutical Development and Technology·P WehrleS Benita
Jul 9, 2002·Drug Development and Industrial Pharmacy·Indu Pal Kaur, Meenakshi Kanwar
Oct 27, 2011·Biopharmaceutics & Drug Disposition·Medhat W ShafaaRehab A Fouad
Mar 23, 2019·Nanomedicine·Aseel Mahmood Ibrahim Al-MashahedahJagat Rakesh Kanwar
May 1, 1989·International Ophthalmology·V S RaoS Vangipuram
Aug 15, 2014·Drug Delivery·Renu AgarwalNafeeza Mohd Ismail
Mar 8, 2005·Survey of Ophthalmology·Shehab EbrahimPaul J Lee

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