A preliminary study of increased amygdala activation to positive affective stimuli in mania

Bipolar Disorders
Felix BermpohlMichael Bauer

Abstract

The present study in hypomanic and manic patients explored how amygdala responses to affective stimuli depend on the valence of the stimuli presented. We compared 10 patients with 10 matched healthy control subjects. We measured blood oxygen level-dependent (BOLD) responses in the amygdala while subjects passively viewed photographs taken from the International Affective Picture System. After the fMRI session, subjects saw the pictures again and subjectively rated the emotional valence and intensity of each picture. Compared to healthy individuals, hypomanic or manic patients showed higher valence ratings in positive pictures and associated larger BOLD responses in the left amygdala during positive versus neutral picture viewing. This enhanced amygdala activation was correlated with Young Mania Rating Scale scores and with euphoric as opposed to irritable symptom presentation. Increased valence ratings and amygdala responses to positive affective stimuli may reflect a positive processing bias contributing to elevated mood states characteristic for euphoric mania.

References

Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Oct 1, 1996·The British Journal of Psychiatry : the Journal of Mental Science·A H al-MousawiG W Ashcroft
Nov 1, 1996·Behaviour Research and Therapy·B P BradleyN Millar
Jul 1, 1997·Comprehensive Psychiatry·C Zlotnick, T Pearlstein
Oct 31, 1998·Psychiatry Research·W W Hale
Mar 17, 1999·Archives of General Psychiatry·S M StrakowskiE R Larson
Jun 18, 1999·The International Journal of Neuroscience·R Lior, I Nachson
Jan 5, 2000·Psychological Medicine·F C MurphyE S Paykel
Mar 13, 2001·Molecular Psychiatry·M Davis, P J Whalen
Oct 2, 2001·The American Journal of Psychiatry·L ClarkG M Goodwin
Feb 2, 2002·The American Journal of Psychiatry·Anna Lembke, Terence A Ketter
Apr 2, 2003·NeuroImage·Stephan F TaylorIsrael Liberzon
Aug 30, 2003·Biological Psychiatry·Mary L PhillipsRichard Lane
Aug 30, 2003·Biological Psychiatry·Mary L PhillipsRichard Lane
Feb 27, 2004·The European Journal of Neuroscience·Gin S MalhiPerminder Sachdev
Sep 2, 2004·Molecular Psychiatry·S M StrakowskiC M Adler
May 3, 2005·NeuroImage·Tor D WagerJohn Jonides
Jun 3, 2005·The American Journal of Psychiatry·Lori AltshulerMark S Cohen
Sep 24, 2005·Bipolar Disorders·Tomas HajekMartin Alda
Feb 5, 2008·The American Journal of Psychiatry·Mary L PhillipsDavid J Kupfer

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Citations

May 29, 2012·European Archives of Psychiatry and Clinical Neuroscience·Dominik GrotegerdUdo Dannlowski
Dec 15, 2010·Social Cognitive and Affective Neuroscience·Gabriel S DichterJames W Bodfish
Dec 24, 2013·L'Encéphale·A KaladjianJ-M Azorin
Aug 4, 2012·Biological Psychiatry·Jennifer D TownsendLori L Altshuler
Apr 8, 2011·Journal of Affective Disorders·Josselin HouenouMichèle Wessa
Jun 24, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Lorna SchlochtermeierAndreas Ströhle
Sep 29, 2011·Clinical Psychology & Psychotherapy·June Gruber
May 29, 2012·Bipolar Disorders·Jennifer Townsend, Lori L Altshuler
Feb 16, 2011·Bipolar Disorders·Chi-Hua ChenEd T Bullmore
Dec 2, 2009·Human Brain Mapping·Felix BermpohlAndreas Heinz
Jul 13, 2014·Journal of Psychiatric Research·John O Brooks, Nathalie Vizueta
Nov 2, 2014·Bipolar Disorders·Andrew K DavisCaleb M Adler
Aug 15, 2014·European Archives of Psychiatry and Clinical Neuroscience·Katharina StegmayerOliver Gruber
Mar 15, 2012·Psychiatry Research·Katia M'BailaraChantal Henry
Apr 19, 2011·Journal of Affective Disorders·Racheal DegabrieleGin Malhi
May 1, 2016·Neuroscience Letters·Claudia HägeleAndreas Heinz
Jul 1, 2013·Emotion Review : Journal of the International Society for Research on Emotion·Derek M IsaacowitzSheri L Johnson
Jul 1, 2014·World Journal of Radiology·Gianna SepedeFrancesco Gambi
Jun 15, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Shokouh ArjmandMohammad Shabani
Dec 21, 2012·Expert Review of Neurotherapeutics·Sandy KuiperGin S Malhi
Mar 25, 2017·Social Cognitive and Affective Neuroscience·Katherine S DammeRobin Nusslock
Sep 21, 2021·Nordic Journal of Psychiatry·Harun Olcay SonkurtFerdi Köşger

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