A preliminary study of serum IgE against cross-reactive carbohydrate determinants (CCD) in client-owned atopic dogs

Veterinary Dermatology
Britt J Levy, Douglas J DeBoer

Abstract

Cross-reactive carbohydrate determinants (CCD) are defined carbohydrate portions of glycoprotein cell surface molecules common to many plant and insect species. Mammalian species recognize CCD as foreign antigens and can mount humoral immune responses against them. Approximately 20-37% of grass and venom allergic people possess circulating IgE against CCD; these antibodies are generally considered clinically irrelevant. Anti-CCD IgE is, however, recognized as a cause of false positive, clinically incongruent serum allergen test results in people; this phenomenon has not been investigated in animals. To determine if anti-CCD IgE could be detected in sera of client-owned atopic dogs and how frequently it is found. Sera from 38 dogs with a clinical diagnosis of atopic dermatitis and prior serological evidence of IgE antibodies, defined as a positive result to at least one mite and pollen (of any type). Sera were analysed for IgE against CCD and environmental allergens with a commercially available multiplex enzyme-labelled allergen-specific IgE assay. Anti-CCD IgE was detected in nine of 38 (24%) of atopic dog sera. As with their human counterparts, all dogs with anti-CCD IgE had strong serological reactivity to grass pollens. Ant...Continue Reading

References

Aug 1, 1993·Veterinary Immunology and Immunopathology·D J DeBoerK T Schultz
Jan 1, 1997·Clinical Reviews in Allergy & Immunology·R C Aalberse, R van Ree
Jan 15, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D G EboW J Stevens
Oct 12, 2011·International Archives of Allergy and Immunology·Carmen VidalArturo Gonzalez-Quintela
Sep 23, 2016·Allergo Journal International·Friedrich Altmann

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Citations

Oct 24, 2019·Veterinary Dermatology·Michelle L Piccione, Douglas J DeBoer
Dec 5, 2020·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Amirhossein MohammaddavoodiRegina Wagner
May 19, 2021·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Amirhossein MohammaddavoodiRegina Wagner

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