A preliminary study of solid embryonic cerebellar graft survival in adult B6CBA Lurcher mutant and wild type mice

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Jan CendelínFrantisek Vozeh

Abstract

Lurcher mutant mice represent a model of olivocerebellar degeneration. They suffer from complete loss of Purkinje cells and a reduction of granule cells and inferior olive neurons. Their wild type littermates serve as healthy controls. The aim of the work was to compare solid embryonic cerebellar graft survival within a period of 9 weeks after their transplantation in adult Lurcher mutant and wild type mice of the B6CBA strain. The solid grafts were injected through a hole in the occipital bone. Host mice were sacrificed 3, 6, or 9 weeks after the transplantation and their cerebella and brain-stems were examined histologically to assess graft presence and structure. We did not find significant differences in graft survival rates between Lurcher mutant and wild type mice. The frequency of graft presence did not differ between mice examined 3, 6, and 9 weeks after the transplantation, neither in Lurchers nor in wild type mice. The grafts were of various sizes. In some cases, only small residua of the grafts were found. Nerve fiber sprouting and cell migration from the graft to the host tissue were observed more often in wild type mice than in Lurchers when examined 6 weeks after surgery. In the period 3-9 weeks after transplantat...Continue Reading

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Citations

Apr 27, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zbyněk HoudekFrantišek Vožeh
Mar 21, 2012·Neuroscience Letters·Jan CendelínFrantišek Vožeh
Nov 28, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Roland Pochet, Jean-Pierre Timmermans
Nov 26, 2013·Neuroscience Letters·Zdenka PurkartovaJan Cendelin
Feb 17, 2018·The Cerebellum·Jan CendelinYaroslav Kolinko

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