PMID: 40800Aug 1, 1979

A preliminary study of the effects of prepeated doses of clobazam on aspects of performance, arousal and behaviour in a group of anxiety rated volunteers

European Journal of Clinical Pharmacology
I Hindmarch

Abstract

Repeated doses of a 1,5 benzodiazepine, clobazam, were administered to a group of consenting volunteers. Performance on a psychomotor performance task was not impaired by repeated doses of the drug. Subjective assessments of anxiety were reduced commensurate with an increase in the level of cortical integration, measured via critical flicker fusion thresholds, suggesting that the anxiolytic activity of the drug is related to its effect on arousal. Important differences were found between the responses of high and low anxiety subjects on objective measures of performance and arousal and on self-completion analogue rating scales.

References

Jan 1, 1987·European Journal of Clinical Pharmacology·A PatatM Hucher
Jan 3, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yu-tze Ng, Stephen D Collins
Sep 1, 1980·British Journal of Clinical Pharmacology·I Hindmarch
Aug 1, 1980·British Journal of Clinical Pharmacology·I Hindmarch, A C Gudgeon
Jul 1, 1985·British Journal of Clinical Pharmacology·A Patat, P Foulhoux

Citations

Oct 1, 1977·British Journal of Clinical Pharmacology·I HindmarchA J Hewett
Jan 1, 1979·British Journal of Clinical Pharmacology·W RuppO Vanderbeke
Jan 1, 1979·British Journal of Clinical Pharmacology·I Hindmarch
Feb 1, 1975·British Journal of Clinical Pharmacology·J W DundeeJ D Morrison
Mar 1, 1973·Pharmakopsychiatrie, Neuro-Psychopharmakologie·M Linnoila, M J Mattila
Nov 1, 1972·The Quarterly Journal of Experimental Psychology·A S ChamoveH F Harlow
Jan 1, 1970·The British Journal of Psychiatry : the Journal of Mental Science·S CrownR W Howell
Feb 1, 1967·Journal of Personality and Social Psychology·G S BlumC G Stewart
Sep 14, 1963·Nature·H J EYSENCK
Mar 1, 1955·Journal of Experimental Psychology·S GOLDSTONE
Jul 20, 2012·Nepal Medical College Journal : NMCJ·B ShresthaS Dhungel

Related Concepts

Nervousness
Vigilance, Cortical
Motor Skills
Reaction Time
Anti-Anxiety Effect
Relaxation
Anxiety Disorders
Benzodiazepinones
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