A preliminary study on efficacy of rupatadine for the treatment of acute dengue infection

Scientific Reports
Gathsaurie Neelika MalavigeGraham S Ogg

Abstract

Currently there are no specific treatments available for acute dengue infection. We considered that rupatadine, a platelet-activating factor receptor inhibitor, might modulate dengue-associated vascular leak. The effects of rupatadine were assessed in vitro, and in a dengue model, which showed that rupatadine significantly reduced endothelial permeability by dengue sera in vitro, and significantly inhibited the increased haematocrit in dengue-infected mice with dose-dependency. We conducted a randomised, placebo-controlled trial in 183 adult patients in Sri Lanka with acute dengue, which showed that rupatadine up to 40 mg daily appeared safe and well-tolerated with similar proportions of adverse events with rupatadine and placebo. Although the primary end-point of a significant reduction in fluid leakage (development of pleural effusions or ascites) was not met, post-hoc analyses revealed small but significant differences in several parameters on individual illness days - higher platelet counts and lower aspartate-aminotransferase levels on day 7 in the rupatadine group compared to the placebo group, and smaller effusions on day 8 in the subgroup of patients with pleural effusions. However, due to the small sample size and rang...Continue Reading

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Citations

Nov 18, 2020·Scientific Reports·Shashika DayarathnaGathsaurie Neelika Malavige
Feb 6, 2021·PloS One·Tehani SilvaGathsaurie Neelika Malavige
Nov 20, 2020·Tropical Medicine and Infectious Disease·N L Ajantha ShyamaliGathsaurie Neelika Malavige
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Gathsaurie Neelika MalavigeGraham S Ogg
Mar 7, 2021·Journal of Clinical Medicine·Matthijs RaadsenMarco Goeijenbier
Jul 5, 2021·European Journal of Clinical Pharmacology·Tarek Mohamed MostafaFedaa Abd El-Monem Kotkata
Aug 20, 2021·PLoS Neglected Tropical Diseases·Gathsaurie Neelika MalavigeHasitha Tissera

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