A preliminary study on MeO-PEG-PLGA-PEG-OMe nanoparticles as intravenous carriers

Journal of Biomedical Materials Research. Part a
Yourong DuanZhirong Zhang

Abstract

To develop an intravenous nanoparticle delivery system for a cancer drug (i.e., DHAQ, mitoxantrone), the synthesis of a biodegradable polyester polymer with hydrophilic polyethylene glycol chains, preparation of DHAQ-loaded nanoparticles from such polymer and biodistribution of the drug-loaded particles were investigated in this article. Biodegradable monomethoxy poly(ethylene glycol)-poly (lactide-co-glycolide)-monomethoxy poly(ethylene glycol) (MeO-PEG-PLGA-PEG-OMe, PELGE) copolymers were synthesized by ring-opening polymerization as the drug carriers. A double emulsion method with dextran-70 as an emulsifier was employed to prepare the nanoparticles. DHAQ-PELGE nanoparticles and free DHAQ were employed for the in vivo biodistribution studies after intravenous administration through the tail veins in mice. At various time intervals, the mice were sacrificed and several organs and tissues harvested, including hearts, livers, spleens, lungs, kidneys, and blood. The DHAQ concentrations in the collected tissues and plasmas were determined using high performance liquid chromatography. The DHAQ concentrations in mice plasmas in the experimental groups were significantly higher than those in the control group and 3.72% of total admi...Continue Reading

References

Jan 1, 1978·Annual Review of Microbiology·C J van Oss
Sep 30, 1991·Biochimica Et Biophysica Acta·T M Allen, C Hansen
Mar 18, 1994·Science·R GrefR Langer
Mar 29, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y LiX Gao
Jun 9, 2001·International Journal of Pharmaceutics·Z PanagiK Avgoustakis
Aug 15, 2002·International Journal of Pharmaceutics·Tanima BanerjeeAmarnath Maitra
Dec 20, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·L Mu, S S Feng
May 8, 2003·Journal of Biomedical Materials Research. Part a·Leo Vroman
Jun 24, 2003·Pharmaceutical Research·Zhenhua LiLeaf Huang
Nov 13, 2003·Journal of Biomedical Materials Research. Part a·Yoon Jeong ParkSeung Jin Lee
Feb 27, 2004·Pharmaceutical Research·Ji Hoon JeongTae Gwan Park
Apr 10, 2004·International Journal of Pharmaceutics·V R SinhaS Dhawan
Jun 3, 2005·Chemical & Pharmaceutical Bulletin·Xun SunZhi-Rong Zhang
Oct 19, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sridhar DuvvuriAshim K Mitra
Jan 5, 2006·Journal of Biomedical Materials Research. Part a·Diederik H R KempenMichael J Yaszemski
Feb 14, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bin LuRuo-Bing Chao
Apr 8, 2006·International Journal of Pharmaceutics·Kathleen DillenAnnick Ludwig
May 13, 2006·Journal of Materials Science. Materials in Medicine·Yourong DuanZhirong Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.