A preliminary trial of high-dose ursodeoxycholic acid in primary sclerosing cholangitis

Gastroenterology
S A MitchellR W Chapman

Abstract

Ursodeoxycholic acid (UDCA) is used for the treatment of cholestatic liver diseases including primary biliary cirrhosis (PBC) for which it has a positive effect on laboratory values, may delay the development of liver failure and prolong the transplant-free disease period. Standard doses of UDCA (8-15 mg/kg daily) have been shown to be ineffective in the treatment of primary sclerosing cholangitis (PSC). We report on the findings (clinical, biochemical, histological, and cholangiographic) and side effects of a 2-year double-blind placebo-controlled preliminary study of high-dose UDCA in PSC patients. Twenty-six patients with PSC were randomized to high-dose (20 mg/kg daily) UDCA or placebo. Cholangiography and liver biopsy were performed at entry and after 2 years. Symptoms, clinical signs, and liver biochemical tests were recorded at 3 monthly intervals. High-dose UDCA did not influence symptoms, but there was a significant improvement in liver biochemistry (serum alkaline phosphatase, P = 0.03; gamma-glutamyl transferase, P = 0.01) and a significant reduction in progression in cholangiographic appearances (P = 0.015) and liver fibrosis as assessed by disease staging (P = 0.05). In the treatment group, a significant increase i...Continue Reading

References

Dec 1, 1992·Gastroenterology·E R DicksonM M Kaplan
Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U BeuersG Paumgartner
Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M YoshikawaS Ishizaka
Jun 1, 1991·Gastroenterology·J M FarrantR Williams
Nov 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C B O'BrienG Salen
Jul 1, 1990·Journal of Hepatology·O ChazouillèresJ C Trinchet
Feb 1, 1991·Seminars in Liver Disease·O FausaK Elgjo
Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MarteauR Poupon
Sep 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P R GalleA Stiehl
Dec 1, 1989·Digestive Diseases and Sciences·M PoddaM Zuin
Oct 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R H WiesnerN F LaRusso
Nov 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J LudwigJ T McCall
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Dec 1, 1994·Journal of Hepatology·E SchrumpfF Kolmannskog
May 1, 1994·Gastroenterology·K D LindorS M Lange
Oct 1, 1995·Journal of Clinical Pathology·R OlssonS Wallerstedt
Feb 1, 1997·Alimentary Pharmacology & Therapeutics·S A Mitchell, R W Chapman
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I W GraziadeiR A Krom
Nov 24, 1999·The American Journal of Gastroenterology·P AnguloK D Lindor
Jun 10, 2000·Liver·P J Gow, R W Chapman

❮ Previous
Next ❯

Citations

Nov 7, 2001·Current Treatment Options in Gastroenterology·Young-Mee Lee, David J. Kim
Aug 10, 2001·Journal of Hepatology·K N LazaridisK D Lindor
Feb 20, 2003·Journal of Hepatology·Cynthia Levy, Keith D Lindor
Jul 9, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R W Chapman
Jul 9, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·L OkolicsanyiM Zuin
Jan 1, 2009·Therapeutic Advances in Gastroenterology·Gideon M HirschfieldE Jenny Heathcote
Feb 18, 2011·The Journal of Veterinary Medical Science·Takafumi OsumiHajime Tsujimoto
Jan 18, 2008·World Journal of Gastroenterology : WJG·Rebecca Saich, Roger Chapman
Jun 6, 2008·World Journal of Gastroenterology : WJG·Marina-G Silveira, Keith-D Lindor
Dec 29, 2000·Journal of Clinical Gastroenterology·P Angulo, K D Lindor
Apr 2, 2002·The American Journal of Gastroenterology·Young-Mee LeeUNKNOWN Practice Guideline Committee of the ACG. American College of Gastroenterology
Jul 23, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Toshimichi TakigawaJunji Yamamoto
Aug 22, 2014·Journal of Pediatric Gastroenterology and Nutrition·Hanh D VoSteven M Schwarz
Oct 13, 2006·Current Opinion in Gastroenterology·Charles N Bernstein
Feb 28, 2020·Expert Opinion on Investigational Drugs·Christopher ChangM Eric Gershwin
Aug 8, 2002·Journal of Gastroenterology and Hepatology·Tiing Leong AngJessica Yi-Lyn Tan
Jul 16, 2003·Journal of Internal Medicine·Z Ben-AriT Klein
Jan 21, 2011·The Cochrane Database of Systematic Reviews·Goran PoropatChristian Gluud
Apr 15, 2020·British Journal of Clinical Pharmacology·Mario Simental-MendíaLuis E Simental-Mendía
Jun 29, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ivo W Graziadei
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keith D LindorPatrick Colin
Sep 7, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daniel RostAdolf Stiehl
Jan 28, 2005·European Journal of Gastroenterology & Hepatology·Stefano Bellentani
May 5, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·Olivier Chazouillères, Christophe Corpechot
Jun 15, 2006·World Journal of Gastroenterology : WJG·Thomas Pusl, Ulrich Beuers
Oct 26, 2006·Orphanet Journal of Rare Diseases·Joy Worthington, Roger Chapman
Oct 13, 2006·Current Opinion in Gastroenterology·Jayant A Talwalkar, Keith D Lindor
May 10, 2007·European Journal of Gastroenterology & Hepatology·Gerda RudolphAdolf Stiehl
Oct 18, 2007·Digestive Diseases and Sciences·Paul AnguloKeith D Lindor
May 27, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jian ShiWei-Fen Xie
Apr 29, 2010·Current Gastroenterology Reports·Claudia O Zein, Keith D Lindor
Dec 3, 2010·Journal of Crohn's & Colitis·Gert Van AsscheUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Jun 22, 2011·Digestive Diseases·Keith D Lindor
May 4, 2011·NMR in Biomedicine·Patrícia M NunesRui A Carvalho
Feb 13, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ewa WunschPiotr Milkiewicz
Jun 20, 2015·Terapevticheskiĭ arkhiv·O M Drapkina, E L Bueverova
Feb 20, 2015·Current Opinion in Gastroenterology·Elisabeth M G de VriesCyriel Y Ponsioen
Sep 18, 2015·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Mohamed M Abdel-LatifJohn V Reynolds
Oct 31, 2017·Expert Review of Gastroenterology & Hepatology·Stefano GittoPietro Andreone
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gustav Paumgartner, Ulrich Beuers
Mar 12, 2003·Current Treatment Options in Gastroenterology·Cynthia Levy, Keith D. Lindor
Aug 23, 2002·European Journal of Clinical Investigation·G RudolphA Stiehl
Jan 18, 2003·Current Gastroenterology Reports·Roger W Chapman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.