Abstract
Cardiotonic pill (CP) is a pharmaceutical preparation of the herbal medicine Salvia miltiorrhiza. In vitro studies demonstrate that CP inhibits vascular endothelial expression of adhesion molecules and smooth-muscle proliferation, implying the possibility of antiatherosclerotic effects. This study employs an in vivo animal model to examine the potential therapeutic efficacy of CP on atherosclerotic development. Male apolipoprotein E-deficient (ApoE-/-) mice fed with an atherogenic (high fat) diet were administered with CP (90-120 mg/kg per day) via drinking water for 8 weeks. Hypercholesterolemia developed in the mice, with 22-fold increases in plasma levels of total cholesterol, 29-fold of LDL, and 7-fold of HDL. CP therapy did not significantly alter the lipid levels. Expression of intercellular adhesion molecule 1 significantly increased in circulating leukocytes and was abolished by CP therapy. Atherosclerosis significantly developed in the aorta and was attenuated by CP therapy, with an approximately 30% reduction in whole atherosclerotic lesions and an approximately 50% reduction in fibrous plaques in the artery. Thus, herbal medicine CP partly protects ApoE-/- mice from high-fat diet-induced atherogenesis. The protection...Continue Reading
References
Sep 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J H QiaoA J Lusis
Feb 15, 1996·Circulation·K D O'BrienC E Alpers
Jul 1, 1997·Journal of Vascular Surgery·A B LumsdenL A Harker
Jul 22, 1998·Nature·F MachP Libby
Jan 14, 1999·The New England Journal of Medicine·R Ross
Feb 8, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G Y ZhouW J Xin
Jul 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·A J CayatteR A Cohen
Jul 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·S OguchiB Cercek
Sep 19, 2000·Free Radical Research·X L NiuH Nakazawa
Aug 14, 2001·Journal of Cellular Biochemistry·Y H ChenY L Chen
Oct 27, 2001·Acta Physiologica Scandinavica·Y Huo, K Ley
Dec 25, 2002·Japanese Journal of Pharmacology·De Cheng RenJun Tian Zhang
Nov 13, 2003·Atherosclerosis·Stefan BlankenbergLaurence Tiret
May 18, 2004·Journal of Neuroimmunology·Mary Ann T GimenezJohn H Russell
Dec 29, 2004·Journal of Pharmaceutical and Biomedical Analysis·Jin-lan ZhangDe-an Guo
May 10, 2005·European Journal of Pharmacology·Zhe ZhouSheng-Qi Wang
May 18, 2005·Journal of Cardiovascular Pharmacology·Mei DingZhi-Xin Guo
Jul 20, 2005·Clinical and Experimental Pharmacology & Physiology·Shanhong LingPaul A Komesaroff
Oct 7, 2005·International Journal of Cardiology·Daniel P SievekingDavid S Celermajer
Nov 18, 2005·Journal of Clinical Pharmacology·Limin ZhouMoses Sing Sum Chow
Oct 21, 2006·International Immunopharmacology·C K WongC W K Lam
Citations
Feb 10, 2012·Phytotherapy Research : PTR·Shuhong QianQingwen Qian
Oct 5, 2011·Echocardiography·Jing TianKan Liu
Dec 26, 2012·Biochemical and Biophysical Research Communications·Seung-Lark HwangHyeun Wook Chang
Jul 22, 2011·Atherosclerosis·Si GaoSuowen Xu
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Kylie A O'BrienPaul A Komesaroff
Jul 23, 2015·Scientific Reports·Fang LongPing Li
Nov 18, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Shanhong LingPaul A Komesaroff
Apr 27, 2018·Acta Pharmacologica Sinica·Zhuo-Ming LiPei-Qing Liu
Mar 1, 2018·Pharmaceutical Biology·Emily Guzman, Jeanmaire Molina
Sep 15, 2019·Fundamental & Clinical Pharmacology·Junjian WangYanfeng Xiao
Nov 27, 2008·Pancreas·Zhang XipingHe Jiao
Aug 24, 2012·Menopause : the Journal of the North American Menopause Society·Chun-mei LiShun-wan Chan
Apr 26, 2016·Journal of Cardiovascular Pharmacology·Liang ChenMei Zhang
Dec 13, 2012·Journal of Cardiovascular Pharmacology·Shanhong LingPaul A Komesaroff
Apr 9, 2014·Journal of Cardiovascular Pharmacology·Haibo XuXiaolin Ye
Jun 25, 2017·Inflammation·Yan XuanQing Xian Luan