A preponderance of small dense LDL is associated with specific insulin, proinsulin and the components of the insulin resistance syndrome in non-diabetic subjects

Diabetologia
S M HaffnerR Bowsher

Abstract

Recently, the presence of small dense low density lipoprotein (LDL) has been postulated to be a stronger risk factor for coronary heart disease than large LDL. While small dense LDL has been associated with individual components of the insulin resistance syndrome such as hypertension, high triglyceride level, low high density (HDL) cholesterol, and diabetes mellitus, there has been little work exploring whether LDL size is decreased in subjects with multiple metabolic disorders. We examined the association of LDL size and pattern to specific insulin (which does not cross-react with proinsulin), proinsulin, increased triglyceride, decreased HDL, hypertension and impaired glucose tolerance in 488 non-diabetic subjects from the San Antonio Heart Study. LDL size was significantly related to specific insulin, proinsulin and the fasting proinsulin/insulin ratio. Small dense LDL was significantly associated with high triglyceride level, decreased HDL cholesterol, hypertension and impaired glucose tolerance. LDL size (A) decreased in a stepwise fashion with increasing number of the metabolic disorders described above (zero 262.6 +/- 9.4; one 257.0 +/- 9.3; two 256.4 +/- 9.4; three 249.0 +/- 9.1; and four 244.9 +/- 9.0). These results w...Continue Reading

References

Dec 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·K R FeingoldR M Krauss
Feb 11, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·H CamposE J Schaefer
Feb 1, 1991·Diabetes Care·S M HaffnerM P Stern
May 1, 1990·The Journal of Clinical Endocrinology and Metabolism·M F SaadD Porte
Jun 1, 1990·Clinical Endocrinology·R C TempleC N Hales
Feb 11, 1989·Lancet·R C TempleC N Hales
Oct 1, 1988·Metabolism: Clinical and Experimental·A GargP Raskin
Apr 1, 1988·Metabolism: Clinical and Experimental·S M HaffnerJ K Patterson
Aug 6, 1987·The New England Journal of Medicine·E FerranniniS Bevilacqua
Oct 7, 1988·JAMA : the Journal of the American Medical Association·M A AustinR M Krauss
Jul 24, 1986·The New England Journal of Medicine·S M HaffnerJ K Patterson
Nov 28, 1986·JAMA : the Journal of the American Medical Association·W P CastelliW B Kannel
Mar 1, 1985·The Journal of Clinical Investigation·M ModanZ Fuchs
Jan 1, 1971·Annals of Internal Medicine·W B KannelP M McNamara
Sep 1, 1983·American Journal of Epidemiology·T J OrchardA L Drash
Jan 1, 1984·Progress in Lipid Research·F Schroeder
Oct 1, 1994·Diabetes Care·S M HaffnerB V Howard
Dec 1, 1994·The Journal of Clinical Endocrinology and Metabolism·S M HaffnerR R Bowsher
Nov 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S M HaffnerB V Howard
Jul 1, 1993·The Journal of Clinical Investigation·G M ReavenR M Krauss
Aug 1, 1993·Journal of the American College of Cardiology·E D Frohlich
May 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·M J DaviesC N Hales
May 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·M J DaviesC N Hales

❮ Previous
Next ❯

Citations

Jan 1, 1997·Genetic Epidemiology·K L EdwardsM A Austin
May 16, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·L Sorell, R Simón
Dec 2, 1999·Atherosclerosis·D L Rainwater
Sep 5, 2003·Life Sciences·Bo Isomaa
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Catherine Y CampbellRoger S Blumenthal
Oct 26, 2000·Current Opinion in Lipidology·J BorénT L Innerarity
Mar 26, 2005·JAAPA : Official Journal of the American Academy of Physician Assistants·Jeffrey Rassman, Sanjay Gupta
Oct 16, 2007·International Journal of Clinical Practice·M Rizzo, K Berneis
Mar 24, 2010·Diabetology & Metabolic Syndrome·Dal-Sik KimSeul-Ki Jeong
Jun 14, 2000·Drugs·J D Best, D N O'Neal
Jan 18, 2006·Internal Medicine·Ryuichi KawamotoAtsushi Kamitani
Feb 19, 2010·Journal of Cardiovascular Medicine·Kota J ReddyRichard R Batsell
Feb 9, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·T Jenssen
Nov 5, 1997·Annals of the New York Academy of Sciences·T Temelkova-KurktschievW Leonhardt
Nov 5, 1997·Annals of the New York Academy of Sciences·S M Haffner
Apr 21, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Manfredi RizzoJelena Vekic
Aug 1, 1997·The American Journal of Medicine·S M Haffner, H Miettinen
Nov 3, 2006·Diabetes/metabolism Research and Reviews·Manfredi Rizzo, Kaspar Berneis
Jun 5, 1999·The American Journal of Cardiology·S M Grundy
Oct 16, 2015·Metabolic Syndrome and Related Disorders·Yaeko WatabeNaoto Shimura
Sep 3, 2005·European Journal of Internal Medicine·J T TamsmaM V Huisman
Jun 15, 2005·Diabetes Research and Clinical Practice·Robert S Rosenson
Dec 17, 1997·The American Journal of Cardiology·J F AscasoR Carmena
Nov 26, 2002·Obesity Research·F Xavier Pi-Sunyer
Feb 28, 2001·American Journal of Epidemiology·U LindbladE L Barrett-Connor
Sep 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·S M HaffnerB V Howard
Jul 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·L MykkänenM Laakso
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·R S GrayB V Howard
Sep 9, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·J HultheB Fagerberg
Dec 22, 2006·European Journal of Clinical Investigation·A M J WassinkF L J Visseren
Jun 26, 2001·European Journal of Clinical Nutrition·L HåglinL O Bygren
Jan 1, 1995·International Ophthalmology·V Lakshminarayanan, J M Enoch

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.