PMID: 9442104Feb 28, 1998Paper

A presumptive developmental role for a sea urchin cyclin B splice variant

The Journal of Cell Biology
J C LozanoA Picard

Abstract

We show that a splice variant-derived cyclin B is produced in sea urchin oocytes and embryos. This splice variant protein lacks highly conserved sequences in the COOH terminus of the protein. It is found strikingly abundant in growing oocytes and cells committed to differentiation during embryogenesis. Cyclin B splice variant (CBsv) protein associates weakly in the cell with Xenopus cdc2 and with budding yeast CDC28p. In contrast to classical cyclin B, CBsv very poorly complements a triple CLN deletion in budding yeast, and its microinjection prevents an initial step in MPF activation, leading to an important delay in oocyte meiosis reinitiation. CBsv microinjection in fertilized eggs induces cell cycle delay and abnormal development. We assume that CBsv is produced in growing oocytes to keep them in prophase, and during embryogenesis to slow down cell cycle in cells that will be committed to differentiation.

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Citations

Jun 25, 2003·Biochemical and Biophysical Research Communications·Magali Le BretonJulia Morales
Apr 8, 2003·Developmental Biology·Ekaterina VoroninaGary M Wessel
Feb 13, 2001·Biochemical and Biophysical Research Communications·F MarquésA M Genevière
Jan 15, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Virak VisudtipholeKanyawim Kirtikara
Apr 24, 2007·Chemico-biological Interactions·Annabel Simon-LevertAnne-Marie Genevière
Mar 4, 2010·Molecular Reproduction and Development·Jean-Claude LozanoGérard Peaucellier
Dec 14, 2002·Biochemical and Biophysical Research Communications·Nicolas OffnerGérard Peaucellier
Nov 3, 2006·Developmental Biology·Antonio Fernandez-GuerraAnne-Marie Genevière
Oct 25, 2016·Molecular Reproduction and Development·Vincent PicardRobert Bellé
Dec 25, 2003·Molecular Reproduction and Development·Trudee FairPatrick Lonergan
Feb 1, 2007·Journal of Cell Science·Raïssa EluèreMarie-Noëlle Simon
Sep 28, 2000·Biochemical and Biophysical Research Communications·J C SergèreF Leteurtre
Mar 19, 2002·Chemical Research in Toxicology·Julie MarcRobert Bellé

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