A preventive injection of endothelial progenitor cells prolongs lifespan in stroke-prone spontaneously hypertensive rats

Clinical Science
Cheng PengHe-Hui Xie

Abstract

There is a pressing need for new approaches to prevent stroke. Endothelial progenitor cells (EPCs) promote vascular repair and revascularization in the ischemic brain. The present study sought to evaluate whether preventive delivery of EPCs could prevent or protect against stroke. Stroke-prone spontaneously hypertensive rats (SHR-SP) received a single injection of EPCs, and their survival time was monitored. In addition, at 28 and/or 42 days after a single injection of EPCs, SHR-SP and mice were subjected to cerebral ischemia, and cerebral ischemic injury, local angiogenesis and in vivo EPC integration were determined. Other experiments examined the effects of EPC conditioned medium, and the distribution of donor EPCs taken from GFP transgenic mice. It was found that EPC-pretreated SHR-SP showed longer lifespans than untreated controls. A single preventive injection of EPCs could produce persistent protective effects against cerebral ischemic injury (lasting at least 42 days), and promote local angiogenesis in the ischemic brain, in two types of animals (SHR-SP and normotensive mice). EPCs of donor origin could be detected in the recipient peripheral blood, and integrated into the recipient ischemic brains. Furthermore, it was ...Continue Reading

References

Jan 1, 1976·Stroke; a Journal of Cerebral Circulation·Y YamoriM Fukase
Jan 22, 2005·Annual Review of Medicine·Aarif Y Khakoo, Toren Finkel
Jan 29, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jieli ChenMichael Chopp
May 4, 2010·Annals of Neurology·Yongfeng FanGuo-Yuan Yang
Sep 23, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Akihiko TaguchiRyuji Hata
Nov 10, 2010·The Journal of Clinical Investigation·Eric J MarrotteAlex F Chen
Mar 6, 2012·Translational Stroke Research·Loren E GloverCesar V Borlongan
May 22, 2013·Cell Research·Jin-Min GuoDing-Feng Su
Oct 31, 2014·Stroke; a Journal of Cerebral Circulation·James F MeschiaUNKNOWN Council on Hypertension
Apr 25, 2015·Stroke; a Journal of Cerebral Circulation·Xiao-Hui DongHe-Hui Xie
Jun 4, 2016·Stroke; a Journal of Cerebral Circulation·Gary K SteinbergNeil E Schwartz
Nov 30, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Bao XinHe-Hui Xie

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