PMID: 9537029Jan 1, 1980Paper

A primary immune response to dextran B512 is followed by a period of antigen-specific immunosuppression caused by autoanti-idiotypic antibodies

Scandinavian Journal of Immunology
C Fernandez, G Möller

Abstract

After a primary immune response to the alpha 1-6 epitope of dextran B512, dextran high responder strains exhibit a specific inability to produce IgM and IgG antibodies against this epitope, although they gave an expected secondary response to horse erythrocytes. Spleen cells from dextran-primed and-suppressed mice responded well to dextran after transfer to lethally irradiated previously untreated mice, indicating that tolerance or exhaustive proliferation of dextran reactive B cells is not responsible. Thymus-dependent dextran-protein conjugates also induced specific suppression. Suppression to both dextran and horse erythrocytes could be passively transferred into untreated recipients with immune serum. However, after absorption with horse erythrocytes and dextran, passive serum transfer only suppressed the response to dextran. It is suggested that the specific immunosuppression was caused by the appearance of autoanti-idiotypic antibodies directed against the immunoglobulin receptors of dextran-reactive B cells.

References

Jan 1, 1975·Transplantation Reviews·A Nisonoff, S A Bangasser
Nov 1, 1975·The Journal of Experimental Medicine·E Trenkner, R Riblet
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·L Kluskens, H Köhler
Jan 1, 1968·Advances in Immunology·J W Uhr, G Möller
Oct 1, 1970·Cellular Immunology·M F Greaves, E Möller
Oct 1, 1970·Cellular Immunology·M F GreavesG Möller
Oct 1, 1975·European Journal of Immunology·K Eichmann, K Rajewsky

❮ Previous
Next ❯

Citations

Dec 1, 1987·Veterinary Immunology and Immunopathology·H Wigzell
Dec 28, 2007·Vaccine·Africa González-FernándezCarmen Fernández
Jan 1, 1982·Annals of the New York Academy of Sciences·G MöllerT Ramos
Nov 1, 1990·Cellular Immunology·C Fernandez, G Möller
Oct 3, 2001·International Immunology·M SánchezC Fernández
Feb 1, 1983·Scandinavian Journal of Immunology·D A RivierM F Kagnoff
Oct 1, 1982·Scandinavian Journal of Immunology·C WoodG Möller
Oct 1, 1982·Scandinavian Journal of Immunology·C WoodG Möller
Apr 1, 1984·Scandinavian Journal of Immunology·C Fernandez, G Möller
Aug 1, 1985·European Journal of Immunology·I SeppäläO Mäkelä
Jan 1, 1983·Microbiology and Immunology·S HabaY Matsuoka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.