A primary tumour of the oesophagus with both melanocytic and schwannian differentiation. Melanocytic schwannoma or malignant melanoma?

Journal of Clinical Pathology
R M BrownJ Newman

Abstract

A 76 year old white woman presented with a four month history of dysphagia and weight loss. Clinical, radiological, and endoscopic examination revealed a pigmented mass in the lower third of the oesophagus. The preoperative diagnosis, including biopsy examination, was that of malignant melanoma. Following oesophageal resection, the mass was found to be a localised, relatively superficial tumour with light, electron microscopic, and immunohistochemical features common to both Schwann cells and melanocytes. The patient survived 46 months after surgery and died of a stroke, with no evidence of tumour recurrence. The tumour is presented as a case of melanocytic schwannoma, with unique features when compared with oesophageal melanotic schwannomas and malignant melanomas described in the literature. The differential diagnosis is discussed and an origin from a common precursor cell of neural crest origin is postulated.

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Citations

May 25, 2007·Surgery Today·Toshiteru TokunagaHajime Maeda
Jul 10, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Robert Díaz BeveridgeJoaquín Montalar Salcedo
Apr 2, 2010·Pathology, Research and Practice·Leonidas D Arvanitis
Jun 27, 2006·The Annals of Thoracic Surgery·Bernard J ParkRaja M Flores
Nov 18, 2006·Journal of Clinical Ultrasound : JCU·Yang-Yuan ChenMaw-Soan Soon
Sep 11, 2008·Brain Pathology·Elizabeth M SagatysAmyn M Rojiani

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