PMID: 237498May 1, 1975

A primate model for testing anticonvulsant drugs

Archives of Neurology
B S MeldrumP A Toseland

Abstract

Senegalese baboons (Papio papio), with a natural syndrome of photosensitive epilepsy, consistently show generalized myoclonic jerks if stimulated stroboscopically at hourly intervals, two to eight hours after the intravenous administration of allylglycine, 200 mg/kg. This provides a model for testing the acute antiepileptic effects of established or new drugs. The relationship between concentration of drug, antiepileptic action, and acute neurological toxic effects can be studied. Pnehobarbital (15 mg/kg) and diazepam (0;5 to 1.5 mg/kg) were highly effective in the absence of signs of toxic reaction (plasma levels: phenobarbital sodium, 0.7 to 1.7 mg/100 ml; diazepam, greater than 0.5 mug/ml). After administration of carbamazepine (30 to 40 mg/kg) and diphenylhydantoin sodium (40 to 50 mg/kg), antiepileptic action was seen, but was accompanied by severe toxic signs (nystagmus and ataxia). Sulthiame (20 to 125 mg/kg) and ethosuximide (50 to 100 mg/kg) had little antiepileptic activity and no acute toxic effects. This primate model may aid the identification of new drugs that are active against grand mal seizures and status epilepticus.

Citations

Jan 1, 1979·British Journal of Clinical Pharmacology·B S MeldrumR W Horton
Jan 1, 1977·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·J M Clifford
Jun 19, 1992·Pharmaceutisch Weekblad. Scientific Edition·H J Kupferberg
Oct 1, 1979·Electroencephalography and Clinical Neurophysiology·B S MeldrumJ M Stutzmann
Apr 14, 1978·Psychopharmacology·G Anlezark, B S Meldrum
Jan 1, 1984·Psychopharmacology·E N PetersenR Schmiechen
Dec 1, 1979·Experimental Neurology·B J KaplanG H Glaser
Jan 1, 1989·British Journal of Clinical Pharmacology·B S Meldrum
Apr 29, 2014·Seizure : the Journal of the British Epilepsy Association·Domenico ItalianoUmberto Aguglia
Jun 15, 1979·Experientia·B S Meldrum, R W Horton
Jun 1, 1978·British Journal of Pharmacology·A Gibson, M Samini
Feb 1, 1996·Synapse·M S Starr

Related Concepts

Allyl Compounds
Anticonvulsants
Carbamazepine Sulfate (2: 1)
Chromatography, Gas-Liquid
Valium
Dose-Response Relationship, Drug
Drug Evaluation
Medicinal Plants Testing, Preclinical
Electroencephalogram
Etosuximida Faes

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