A primer on systematic reviews in toxicology

Archives of Toxicology
Sebastian HoffmannKatya Tsaioun

Abstract

Systematic reviews, pioneered in the clinical field, provide a transparent, methodologically rigorous and reproducible means of summarizing the available evidence on a precisely framed research question. Having matured to a well-established approach in many research fields, systematic reviews are receiving increasing attention as a potential tool for answering toxicological questions. In the larger framework of evidence-based toxicology, the advantages and obstacles of, as well as the approaches for, adapting and adopting systematic reviews to toxicology are still being explored. To provide the toxicology community with a starting point for conducting or understanding systematic reviews, we herein summarized available guidance documents from various fields of application. We have elaborated on the systematic review process by breaking it down into ten steps, starting with planning the project, framing the question, and writing and publishing the protocol, and concluding with interpretation and reporting. In addition, we have identified the specific methodological challenges of toxicological questions and have summarized how these can be addressed. Ultimately, this primer is intended to stimulate scientific discussions of the id...Continue Reading

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Citations

Mar 23, 2018·Inhalation Toxicology·L Daniel Maxim, Mark J Utell
Oct 21, 2017·Archives of Toxicology·Marcel LeistJan G Hengstler
Jun 14, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Martin L StephensKatya Tsaioun
Jul 28, 2018·International Journal of Environmental Research and Public Health·Sabine S LangeMichael E Honeycutt
Feb 23, 2019·International Journal of Toxicology·Kristine M AlpiDavid C Dorman
Oct 13, 2018·Toxicology Research·Thomas LuechtefeldThomas Hartung
Feb 26, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Taylor A M WolffePaul Whaley
Dec 29, 2020·Environmental Health Perspectives·Paul WhaleyMichelle Angrish
Dec 16, 2020·Chemical Research in Toxicology·Emily GoldenAlexandra Maertens
Apr 24, 2021·British Journal of Anaesthesia·Jennifer WaspeTom G Hansen
Apr 20, 2021·Regulatory Toxicology and Pharmacology : RTP·Linda Schenk, Gunnar Johanson
May 9, 2021·Regulatory Toxicology and Pharmacology : RTP·Miranda W LangendamCarlijn R Hooijmans
Jun 11, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sebastian HoffmannKatya Tsaioun
Aug 18, 2021·Neurotoxicology·Douglas L Weed

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Software Mentioned

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Google Scholar
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