A principle of economy predicts the functional architecture of grid cells

ELife
Xue-Xin WeiVijay Balasubramanian

Abstract

Grid cells in the brain respond when an animal occupies a periodic lattice of 'grid fields' during navigation. Grids are organized in modules with different periodicity. We propose that the grid system implements a hierarchical code for space that economizes the number of neurons required to encode location with a given resolution across a range equal to the largest period. This theory predicts that (i) grid fields should lie on a triangular lattice, (ii) grid scales should follow a geometric progression, (iii) the ratio between adjacent grid scales should be √e for idealized neurons, and lie between 1.4 and 1.7 for realistic neurons, (iv) the scale ratio should vary modestly within and between animals. These results explain the measured grid structure in rodents. We also predict optimal organization in one and three dimensions, the number of modules, and, with added assumptions, the ratio between grid periods and field widths.

References

Oct 1, 1976·The Journal of Comparative Neurology·O Steward, S A Scoville
Apr 1, 1976·Experimental Neurology·J O'Keefe
Dec 8, 2000·Neural Computation·W Maass
Aug 25, 2001·Annual Review of Neuroscience·E P Simoncelli, B A Olshausen
Dec 12, 2001·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·H SompolinskyM Shamir
Oct 25, 2002·Neural Computation·M BethgeK Pawelzik
Aug 31, 2004·Science·Marianne FyhnMay-Britt Moser
Jun 21, 2005·Nature·Torkel HaftingEdvard I Moser
Jun 9, 2006·Nature Reviews. Neuroscience·Bruno B AverbeckAlexandre Pouget
Nov 10, 2006·Hippocampus·Trygve SolstadGaute T Einevoll
Feb 27, 2007·Nature·Marianne FyhnEdvard I Moser
May 9, 2007·Nature Neuroscience·Caswell BarryKathryn J Jeffery
May 1, 1949·Journal of Mammalogy·L F STICKEL, W H STICKEL
Feb 21, 2008·Annual Review of Neuroscience·Edvard I MoserMay-Britt Moser
Jul 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ila R FieteTed Brookings
Jul 1, 1948·Psychological Review·E C TOLMAN
Feb 1, 1948·Journal of Mammalogy·H S FITCH
Oct 31, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·André A FentonNandor Ludvig
Nov 21, 2008·Hippocampus·Vegard Heimly BrunMay-Britt Moser
Feb 21, 2009·PLoS Computational Biology·Yoram Burak, Ila R Fiete
Mar 21, 2009·Nature Reviews. Neuroscience·N M van StrienM P Witter
Jun 12, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Licurgo de AlmeidaJohn E Lisman
Sep 15, 2009·Nature Neuroscience·Dori DerdikmanEdvard I Moser
Jan 22, 2010·Nature·Christian F DoellerNeil Burgess
Oct 19, 2010·Trends in Cognitive Sciences·Dori Derdikman, Edvard I Moser
Aug 27, 2011·Neuron·Lisa M GiocomoEdvard I Moser
Sep 13, 2011·Nature Neuroscience·Sameet Sreenivasan, Ila Fiete
Nov 5, 2011·Nature·Michael M YartsevNachum Ulanovsky
Nov 22, 2011·Cell·Lisa M GiocomoEdvard I Moser
May 19, 2012·Neural Computation·Alexander MathisMartin Stemmler
Aug 21, 2012·Science·Julija KrupicJohn O'Keefe
Oct 4, 2012·Physical Review Letters·Alexander MathisMartin B Stemmler
Oct 30, 2012·Nature·Nathaniel J KillianElizabeth A Buffalo
Dec 12, 2012·Nature·Hanne StensolaEdvard I Moser
Apr 20, 2013·Science·Michael M Yartsev, Nachum Ulanovsky
Aug 6, 2013·Nature Neuroscience·Joshua JacobsMichael J Kahana
Sep 17, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Alexander MathisMartin B Stemmler
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Benjamin W TowseNeil Burgess
Feb 4, 2014·Trends in Neurosciences·Daniel BushNeil Burgess
Dec 3, 2014·Current Opinion in Neurobiology·Takuya SasakiJill K Leutgeb
Feb 26, 2015·PLoS Computational Biology·Benjamin DunnYasser Roudi
Mar 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jake Ormond, Bruce L McNaughton
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·John L Kubie, Steven E Fox

❮ Previous
Next ❯

Citations

Sep 15, 2018·Hippocampus·Ulises Rodríguez-Domínguez, Jeremy B Caplan
Jan 9, 2018·PLoS Computational Biology·Lajos Vágó, Balázs B Ujfalussy
Dec 14, 2019·Nature Communications·Robert M Mok, Bradley C Love
Mar 30, 2016·Annual Review of Neuroscience·David C RowlandEdvard I Moser
Jan 14, 2017·Physical Review. E·A SanzeniM Vergassola
Oct 23, 2018·ELife·Alexandra T KeinathVijay Balasubramanian
Mar 18, 2016·Physical Review. E·Johnatan AljadeffTatyana O Sharpee
Apr 27, 2021·Frontiers in Computational Neuroscience·Louis KangDmitriy Morozov
May 18, 2021·Neural Networks : the Official Journal of the International Neural Network Society·Suogui DangHuajin Tang

❮ Previous
Next ❯

Software Mentioned

GraphClick

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Benjamin W TowseNeil Burgess
Current Biology : CB
James L Gould
© 2021 Meta ULC. All rights reserved