A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis

Thorax
Anita I R SpanjerReinoud Gosens

Abstract

We have previously shown increased expression of the Frizzled-8 receptor of the Wingless/integrase-1 (WNT) signalling pathway in COPD. Here, we investigated if the Frizzled-8 receptor has a functional role in airway inflammation associated with chronic bronchitis. Acute cigarette-smoke-induced airway inflammation was studied in wild-type and Frizzled-8-deficient mice. Genetic association studies and lung expression quantitative trait loci (eQTL) analyses for Frizzled-8 were performed to evaluate polymorphisms in FZD8 and their relationship to tissue expression in chronic bronchitis. Primary human lung fibroblasts and primary human airway epithelial cells were used for in vitro studies. Cigarette-smoke-exposure induced airway inflammation in wild-type mice, which was prevented in Frizzled-8-deficient mice, suggesting a crucial role for Frizzled-8 in airway inflammation. Furthermore, we found a significant genetic association (p=0.009) between single nucleotide polymorphism (SNP) rs663700 in the FZD8 region and chronic mucus hypersecretion, a characteristic of chronic bronchitis, in a large cohort of smoking individuals. We found SNP rs663700 to be a cis-eQTL regulating Frizzled-8 expression in lung tissue. Functional data link m...Continue Reading

References

Jul 11, 1970·Nature·J P JacobsJ P Baille
Mar 27, 2001·Immunology and Cell Biology·D Knight
Mar 19, 2002·Respirology : Official Journal of the Asian Pacific Society of Respirology·Wan C Tan
Jan 28, 2006·Respiratory Research·Judit E Pongracz, Robert A Stockley
Sep 30, 2006·American Journal of Respiratory and Critical Care Medicine·Roberto de MarcoPeter Burney
Feb 1, 2008·Inhalation Toxicology·Corry-Anke BrandsmaHuib A M Kerstjens
Jul 15, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria V BautistaMary C Rose
Mar 23, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hoeke A BaarsmaReinoud Gosens
Dec 4, 2012·American Journal of Respiratory and Critical Care Medicine·Victor Kim, Gerard J Criner
Dec 5, 2012·PLoS Genetics·Ke HaoDon D Sin
Dec 21, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kuldeep KumawatReinoud Gosens
Feb 12, 2013·The European Respiratory Journal·Loes E M KistemakerReinoud Gosens
Mar 26, 2013·American Journal of Respiratory Cell and Molecular Biology·Verena AumillerMelanie Königshoff
Jun 15, 2013·Experimental & Molecular Medicine·Young Su JungYoe-Sik Bae
Sep 3, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Corry-Anke BrandsmaDirkje S Postma
Feb 11, 2014·Clinics in Chest Medicine·Jørgen Vestbo
Feb 11, 2014·Clinics in Chest Medicine·Peter J Barnes
Apr 10, 2014·PloS One·Akkelies E DijkstraUNKNOWN LifeLines Cohort study
Apr 18, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Christian R OsadnikAnne E Holland
May 9, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Gaetano CaramoriKian Fan Chung
May 13, 2014·Frontiers in Oncology·Pawan KalerLidija Klampfer

❮ Previous
Next ❯

Citations

Mar 1, 2017·American Journal of Respiratory and Critical Care Medicine·Wioletta Skronska-WasekMelanie Königshoff
Apr 19, 2017·Thorax·H A Baarsma, M Königshoff
Aug 4, 2018·The European Respiratory Journal·Hataitip TasenaCorry-Anke Brandsma
Apr 7, 2019·The Journal of Pharmacology and Experimental Therapeutics·Jiao QuHongwei Yao
Oct 16, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Y S Prakash
Jul 28, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qi LiWei Zhang
May 28, 2021·Frontiers in Pharmacology·Alaa Sayed Abou-ElhamdMuhammad Abu-Elmagd

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.