A probabilistic framework for a physiological representation of dynamically evolving sleep state

Journal of Computational Neuroscience
Vera M DadokAndrew J Szeri

Abstract

This work presents a probabilistic method for mapping human sleep electroencephalogram (EEG) signals onto a state space based on a biologically plausible mathematical model of the cortex. From a noninvasive EEG signal, this method produces physiologically meaningful pathways of the cortical state over a night of sleep. We propose ways in which these pathways offer insights into sleep-related conditions, functions, and complex pathologies. To address explicitly the noisiness of the EEG signal and the stochastic nature of the mathematical model, we use a probabilistic Bayesian framework to map each EEG epoch to a distribution of likelihoods over all model sleep states. We show that the mapping produced from human data robustly separates rapid eye movement sleep (REM) from slow wave sleep (SWS). A Hidden Markov Model (HMM) is incorporated to improve the path results using the prior knowledge that cortical physiology has temporal continuity.

References

Sep 29, 2000·IEEE Transactions on Bio-medical Engineering·B KempJ J Oberyé
Apr 24, 2002·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·M L Steyn-RossD T Liley
Jan 18, 2003·Sleep Medicine Reviews·Mario Giovanni Terzano, Liborio Parrino
Sep 2, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Bob Kemp, Jesus Olivan
May 15, 2004·Progress in Biophysics and Molecular Biology·Moira L Steyn-RossJ W Sleigh
Oct 28, 2005·Nature·Clifford B SaperJun Lu
Jan 18, 2006·Sleep·Gabrielle BrandenbergerMartin Buchheit
Jul 20, 2006·Journal of the Royal Society, Interface·Mark A KramerAndrew J Szeri
Aug 10, 2006·Sleep·Bettina MüllerHartmut Schulz
Aug 18, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason B Hardie, Robert A Pearce
Aug 24, 2006·Journal of Computational Neuroscience·M T WilsonI P Gillies
Sep 26, 2006·Journal of Computational Neuroscience·Mark A KramerHeidi E Kirsch
May 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Marcello MassiminiGiulio Tononi
Oct 15, 2008·British Journal of Anaesthesia·E OlofsenA Dahan
Jan 6, 2009·NeuroImage·Moira L Steyn-RossJ W Sleigh
Jan 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael B DashGiulio Tononi
Jul 25, 2009·Sleep & Breathing = Schlaf & Atmung·Saravanan RamGlenn T Clark
Feb 6, 2010·Journal of Computational Neuroscience·Beth A Lopour, Andrew J Szeri
Jun 25, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhong-Wu LiuXiao-Bing Gao
Jun 30, 2010·PLoS Computational Biology·Andrew J K PhillipsRomesh G Abeysuriya
Sep 3, 2010·Journal of Computational Neuroscience·Beth A LopourAndrew J Szeri
Sep 8, 2010·Bulletin of Mathematical Biology·Moira L Steyn-RossM T Wilson
Jun 17, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Balázs HangyaIstván Ulbert
Jun 28, 2011·Science·Daniel BusheyChiara Cirelli
Dec 1, 2005·Journal of Biological Physics·D A Steyn-RossJ J Wright
Jun 5, 2013·Cognitive Neurodynamics·Moira L Steyn-RossJamie W Sleigh

❮ Previous
Next ❯

Citations

Nov 3, 2015·Journal of Neuroscience Methods·R G Abeysuriya, P A Robinson
Nov 13, 2015·International Journal of Neural Systems·N HoumaniF B Vialatte
Apr 29, 2016·International Journal of Neural Systems·Farid YaghoubySridhar Sunderam
Apr 9, 2015·Journal of Computational Neuroscience·Vera M DadokAndrew J Szeri
Aug 29, 2014·Frontiers in Systems Neuroscience·Darren F HightJamie W Sleigh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.