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A probe of the active site acidity of carboxypeptidase A

Biochemistry

May 20, 1986

William L Mock, J T Tsay

PMID: 3718930

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Abstract

The substrate analogue 2-(1-carboxy-2-phenylethyl)-4-phenylazophenol is a potent competitive inhibitor of carboxypeptidase A. Upon ligation to the active site, the azophenol moiety undergoes a shift of pKa from a value of 8.76 to a value of 4.9; this provides an index of the Lewis acidi...read more

Mentioned in this Paper

Azo Compounds
Carboxypeptidase A5
Hydrogen-Ion Concentration
In Vivo NMR Spectroscopy
Carboxypeptidase
2-(1-carboxy-2-phenylethyl)-4-phenylazophenol, (L)-isomer
Paper Details
References
  • References19
  • Citations4
12

A probe of the active site acidity of carboxypeptidase A

Biochemistry

May 20, 1986

William L Mock, J T Tsay

PMID: 3718930

DOI:

Abstract

The substrate analogue 2-(1-carboxy-2-phenylethyl)-4-phenylazophenol is a potent competitive inhibitor of carboxypeptidase A. Upon ligation to the active site, the azophenol moiety undergoes a shift of pKa from a value of 8.76 to a value of 4.9; this provides an index of the Lewis acidi...read more

Mentioned in this Paper

Azo Compounds
Carboxypeptidase A5
Hydrogen-Ion Concentration
In Vivo NMR Spectroscopy
Carboxypeptidase

Related Papers

Paper Details
References
  • References19
  • Citations4
12

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