A probiotic complex, rosavin, zinc, and prebiotics ameliorate intestinal inflammation in an acute colitis mouse model

Journal of Translational Medicine
Jin-Sil ParkMi-La Cho

Abstract

An altered gut microbiota balance is involved in the pathogenesis of inflammatory bowel disease (IBD), and several probiotic strains are used as dietary supplements to improve intestinal health. We evaluated the therapeutic effect of 12 probiotics in combination with prebiotics, rosavin, and zinc in the dextran sodium sulfate (DSS)-induced colitis mouse model. The probiotic complex or the combination drug was administered orally to mice with DSS-induced colitis, and the body weight, disease activity index, colon length, and histopathological parameters were evaluated. Also, the combination drug was applied to HT-29 epithelial cells, and the expression of monocyte chemoattractant protein 1 (MCP-1) was evaluated by real-time polymerase chain reaction. Administration of the combination drug attenuated the severity of DSS-induced colitis. Moreover, the combination drug significantly reduced the levels of the proinflammatory cytokines tumor necrosis factor-α, interleukin (IL)-6, IL-1β, and IL-17, and significantly increased the levels of Foxp3 and IL-10 in colon sections. Additionally, treatment with the combination drug reduced MCP-1 expression in HT-29 cells. Treatment with the combination drug decreased the levels of α-smooth mus...Continue Reading

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Citations

Jun 27, 2018·Current Rheumatology Reports·Chiara Bellocchi, Elizabeth R Volkmann
Nov 26, 2019·Journal of the American College of Nutrition·Monika YadavPratyoosh Shukla
Mar 20, 2019·Autoimmunity·Murillo Duarte-SilvaCristina Ribeiro de Barros Cardoso
Apr 16, 2019·Journal of Immunology Research·Wakana Ohashi, Toshiyuki Fukada
Oct 23, 2020·Chemistry & Biodiversity·Weijie ZhouWeihong Sha
Aug 28, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Daxian LiSun Kwang Kim

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

GraphPad
GraphPad Prism

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