PMID: 8971921Jan 1, 1996Paper

A proenkephalin A-derived peptide analogous to bovine adrenal peptide E from frog brain: purification, synthesis, and behavioral effects

Peptides
J M ConlonH Vaudry

Abstract

A peptide derived from the posttranslational processing of proenkephalin A was isolated from an extract of the brain of the European green frog Rana ridibunda and its primary structure established as: Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg10- Pro-Glu-Trp-Trp-Gln-Asp-Tyr-Gln-Lys-Arg20-Tyr-Gly-Gly-Phe-Met. The structure was confirmed by chemical synthesis. The peptide represents an amphibian equivalent of bovine adrenal peptide E [preproenkephalin A (206-230)-peptide] but the sequence contains two amino acid substitutions (Met15-->Gln and Leu25-->Met) compared with the mammalian peptide. The data support previous hypotheses that the Leu-enkephalin sequence is not present in preproenkephalin A of amphibians. Intracerebroventricular injections of frog peptide E (10 and 100 ng) in mice had no significant effect on horizontal locomotor activity. The peptide, in doses up to 1 microgram, had no effect on latency of escape jumping in the hot plate test and the peptide (100 ng) did not modify responses (paw licking, rearing, and escape jumping) in morphine-treated mice.

References

Jan 1, 1992·International Review of Cytology·A C AndersenH Vaudry
Jan 20, 1992·Brain Research·J BaffiM Palkovits
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·N ChartrelH Vaudry
Sep 22, 1989·European Journal of Pharmacology·D PaulG W Pasternak
Mar 1, 1989·The Journal of Comparative Neurology·I MerchenthalerJ L Maderdrut
Jan 1, 1986·Annual Review of Pharmacology and Toxicology·V Höllt
Feb 15, 1986·Archives of Biochemistry and Biophysics·I Lindberg, L White
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R I Cone, A Goldstein
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D L KilpatrickS Udenfriend
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E WeberC J Evans
Mar 1, 1983·Archives of Biochemistry and Biophysics·S Udenfriend, D L Kilpatrick
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D L KilpatrickS Udenfriend
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R D HowellsS Udenfriend
Aug 29, 1980·Biochemical and Biophysical Research Communications·K MizunoH Matsuo
Oct 1, 1980·Archives of Biochemistry and Biophysics·B N JonesJ E Shively
Jun 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·B Magnus-Ellenbroek, U Havemann-Reinecke
Mar 1, 1957·British Journal of Pharmacology and Chemotherapy·T J HALEY, W G MCCORMICK

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