A profile of amino acid and catecholamine levels during endotoxin-induced acute lung injury in sheep: searching for potential markers of the acute respiratory distress syndrome

The Journal of Laboratory and Clinical Medicine
J M HoffordW Vogel

Abstract

The identification of plasma markers of the course of the acute respiratory distress syndrome (ARDS) is needed to improve its treatment and to further advance the development of new therapeutic agents. The status of markers of lung injury in ARDS is reviewed and some new potential markers are proposed. This study focused on plasma amino acids, related amino compounds, and catecholamine levels during the acute phase of endotoxin-induced lung injury in 8 sheep characterized by the onset of pulmonary edema caused by increased microvascular permeability. A number of significant changes from baseline values were found. During the sixth hour of a 12-hour period of endotoxin infusion, norepinephrine, epinephrine, and alanine levels increased whereas the isoleucine level decreased. During the sixth hour of the immediate postendotoxin period, the taurine level increased while the levels of arginine, citrulline, glycine, isoleucine, methionine, ornithine, serine, threonine, and tryptophan decreased. These findings are compared with prior studies in human subjects detailing the amino acid profile characteristic of advanced sepsis. We conclude that the present profile of catecholamine and amino acid changes during endotoxemia in sheep dese...Continue Reading

References

Nov 1, 1979·Annals of Surgery·H FreundJ E Fischer
Jun 1, 1992·The American Review of Respiratory Disease·A F SuffrediniJ E Parrillo
Dec 1, 1991·The Journal of Clinical Investigation·T J GregoryT M Hyers
Jun 1, 1991·Critical Care Medicine·C L SprungM Pena
Nov 15, 1990·Biochemical and Biophysical Research Communications·R G KilbournR F Lodato
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R G KilbournR F Lodato
Feb 1, 1989·The American Review of Respiratory Disease·S W Chang, N F Voelkel
Aug 1, 1989·The American Review of Respiratory Disease·J E Heffner, J E Repine
Sep 1, 1987·The American Journal of the Medical Sciences·W D LuchtK L Brigham
Mar 1, 1988·The Journal of Pediatrics·J Royall, D L Levin
Jul 1, 1973·Journal of Neurochemistry·J T Coyle, D Henry
Jan 1, 1974·American Journal of Surgery·J E FischerF Deindoerfer
Mar 19, 1970·The New England Journal of Medicine·G F Cahill
May 1, 1983·Annals of Internal Medicine·A A FowlerT M Hyers
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·F SakamakiM Katayama
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·S C DonnellyC Haslett
Jun 1, 1995·Chest·D P Schuster
Feb 11, 1993·The New England Journal of Medicine·R C Bone
Feb 1, 1996·Chest·P KrafftH Steltzer

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Citations

Dec 15, 2015·The British Journal of Nutrition·S O HoskinG E Lobley
May 5, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M V ParseyE Abraham
Nov 2, 2014·Animal Health Research Reviews·Mark Lyte
Aug 16, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·H E DincerB D Uhal
Aug 26, 2000·The Journal of Nutrition·C ChiarlaM Castagneto
May 27, 2016·Microbiology Spectrum·Mark Lyte

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