PMID: 15383590Sep 24, 2004Paper

A profound alteration of blood TCRB repertoire allows prediction of cerebral malaria

The Journal of Immunology : Official Journal of the American Association of Immunologists
Alexis ColletteSylviane Pied

Abstract

Cerebral malaria (CM) is one of the severe complications of Plasmodium infection. In murine models of CM, Talphabeta cells have been implicated in the neuropathogenesis. To obtain insights into the TCRB repertoire during CM, we used high throughput CDR3 spectratyping and set up new methods and software tools to analyze data. We compared PBL and spleen repertoires of mice infected with Plasmodium berghei ANKA that developed CM (CM(+)) or not (CM(-)) to evidence modifications of the TCRB repertoire associated with neuropathology. Using distinct statistical multivariate methods, the PBL repertoires of CM(+) mice were found to be specifically altered. This alteration is partly due to recurrently expanded T cell clones. Strikingly, alteration of the PBL repertoire can be used to distinguish between CM(+) and CM(-). This study provides the first ex vivo demonstration of modifications of Talphabeta cell compartment during CM. Finally, our original approach for deciphering lymphocyte repertoires can be transposed to various pathological conditions.

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Citations

Apr 9, 2013·PloS One·Rosario CastroPierre Boudinot
Sep 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Céline BlacheOlivier Boyer
Feb 6, 2016·PloS One·Encarnita Mariotti-FerrandizAdrien Six
Sep 16, 2016·Frontiers in Immunology·Dongni HouYuanlin Song
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·David BernardAbdenour Benmansour
Mar 26, 2010·Malaria Journal·Yuri C MartinsCláudio T Daniel-Ribeiro
Jan 28, 2006·Parasite Immunology·J C R HafallaF Zavala
Jul 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Blandine Franke-FayardAndrew P Waters

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