A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation.

Nucleic Acids Research
Ivaylo P IvanovAntony J Michael

Abstract

In many eukaryotic mRNAs one or more short 'upstream' open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensors for regulatory circuits and to amplify the signals likely explains their occurrence in most polyamine pathway mRNAs. The uORF-mediated polyamine responsive autoregulatory circuits found in polyamine pathway mRNAs exemplify the translationally regulated dynamic interface between components of the proteome and metabolism.

References

Jan 1, 1984·Annual Review of Biochemistry·C W Tabor, H Tabor
Jan 1, 1996·Trends in Biochemical Sciences·S HayashiS Matsufuji
Mar 25, 2000·Molecular and Cellular Biology·M A HoytR H Davis
Dec 14, 2001·The Journal of Biological Chemistry·Alexa RaneyDavid R Morris
Mar 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Peng FangMatthew S Sachs
Sep 24, 2005·The Journal of Biological Chemistry·Colin HanfreyAnthony J Michael
Nov 3, 2005·The Journal of Biological Chemistry·Kenji HoshinoKazuei Igarashi
Feb 7, 2006·The Journal of Biological Chemistry·Anthony E Pegg
Feb 13, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anne R SimoneauFrank L Meyskens
Mar 20, 2008·American Journal of Physiology. Endocrinology and Metabolism·Anthony E Pegg
Mar 28, 2008·The Journal of Biological Chemistry·Hong WuAlexander N Plotnikov
Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ivaylo P IvanovJohn F Atkins
Nov 13, 2008·The Journal of Biological Chemistry·Xiaojing WangAnthony E Pegg
May 9, 2009·Nature·Preeti SainiThomas E Dever
Sep 19, 2009·Journal of Molecular Biology·Brian D Janssen, Christopher S Hayes

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Citations

Nov 26, 2013·Plant Science : an International Journal of Experimental Plant Biology·Albrecht G von ArnimJustin N Vaughn
Mar 20, 2014·Plant Physiology and Biochemistry : PPB·Israel Maruri-LópezJuan Francisco Jiménez-Bremont
Nov 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Abel RosadoNatasha V Raikhel
Mar 26, 2013·The Journal of Biological Chemistry·Suong NguyenMargaret A Phillips
Mar 1, 2012·Plant & Cell Physiology·Ayaka TakanoTaku Takahashi
Feb 23, 2012·Molecular and Cellular Biology·Oscar Perez-LealSalim Merali
Apr 27, 2012·Comparative and Functional Genomics·Encarnación Martínez-SalasNoemí Fernández
Feb 15, 2011·Cell Division·Woan-Yuh Tarn, Ming-Chih Lai
Aug 3, 2013·The Arabidopsis Book·Bijoyita Roy, Albrecht G von Arnim
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Piyada JuntawongJulia Bailey-Serres
Feb 20, 2014·Journal of Experimental Botany·Abdellah AhouParaskevi Tavladoraki
Mar 5, 2013·Annual Review of Plant Biology·J Bailey-Serres
Oct 29, 2013·Nucleic Acids Research·Klaus WethmarAchim Leutz
Mar 2, 2010·Experimental Cell Research·Kristiina KanervaLeif C Andersson
Jun 7, 2014·Biotechnology Journal·Ju ZhangD Joshua Liao
Jul 15, 2015·Journal of Molecular Biology·Leonor Miller-FlemingMarkus Ralser
Nov 21, 2012·Cell Cycle·Tianyun ZhaoLeah A Vardy
Jun 18, 2016·Science·Alan G HinnebuschNahum Sonenberg
Jul 9, 2016·Plant & Cell Physiology·Qingqing CaiTaku Takahashi
Aug 1, 2018·ELife·Helen Louise LightfootJonathan Hall
Oct 17, 2018·The Journal of Biological Chemistry·Thomas E Dever, Ivaylo P Ivanov
Jul 28, 2011·Endocrine Reviews·Pavine L C LefèvreBruce D Murphy
Nov 29, 2013·Nature·John F Atkins, Pavel V Baranov
Mar 18, 2020·Journal of Biochemistry·Akihiro OguroHiroaki Imataka
Jul 30, 2016·The Biochemical Journal·Anthony J Michael
Jun 9, 2016·The Journal of Biological Chemistry·Anthony E Pegg
Jun 29, 2017·The Biochemical Journal·Anthony J Michael
Jan 18, 2014·Molecular Biology Reports·Maria L Guerrero-GonzálezJuan F Jiménez-Bremont
Sep 2, 2020·Annual Review of Genetics·Thomas E DeverMatthew S Sachs
Jan 31, 2021·Science China. Life Sciences·Guang LiXiao-Long Zhou
Jun 3, 2021·Medical Sciences : Open Access Journal·Shima Nakanishi, John L Cleveland
May 10, 2020·EcoSal Plus·Matthew R HemmGisela Storz

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Datasets Mentioned

BETA
GM079523

Methods Mentioned

BETA
transgenic

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