A prognostic index model to predict the clinical outcomes for advanced pancreatic cancer patients following palliative chemotherapy

Journal of Cancer Research and Clinical Oncology
Peng XueLiwei Wang

Abstract

To establish a prognostic index model for advanced pancreatic cancer patients receiving palliative chemotherapy based on clinical variables. The clinical data of 118 patients with advanced pancreatic cancer who received palliative chemotherapy between January 2006 and August 2013 in our center were retrospectively analyzed. Prognostic factors for overall survival were identified using Cox proportional hazards model. A prognostic index model was established by these pretreatment factors to predict prognosis. Kaplan-Meier estimation and log-rank test were performed to compare the overall survival difference between low-risk and high-risk group of patients. Median overall survival time for all patients was 8.8 months [95% confidence interval (CI) 7.0-10.6 months]. Multivariate analysis identified ECOG score = 2 (hazard ratio 2.03; 95% CI 1.07-3.85; P = 0.030), CA19-9 levels of ≥1000 U/mL (hazard ratio 2.07; 95% CI 1.09-3.92; P = 0.026), and CRP levels of ≥5 mg/L (hazard ratio 2.05; 95% CI 1.06-3.96; P = 0.033) as independent poor prognostic factors for overall survival. For the three factors, ECOG score = 2, CA19-9 levels of ≥1000 U/mL, and CRP levels of ≥5 mg/L were allocated 1 point each. There were 84 (71.2%) patients allocated...Continue Reading

References

Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H A BurrisD D Von Hoff
Mar 13, 2003·International Journal of Gastrointestinal Cancer·Everardo D SaadRené C Gansl
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C LouvetUNKNOWN GISCAD
Jul 19, 2006·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Paul GlenColin J McKay
Aug 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Volker HeinemannRalf Wilkowski
Apr 25, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm J MooreUNKNOWN National Cancer Institute of Canada Clinical Trials Group
May 24, 2007·Cancer Chemotherapy and Pharmacology·Takuji OkusakaHiroshi Saito
Jan 9, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J K PineS H Rahman
Feb 6, 2009·Annals of Surgical Oncology·Matthew H G KatzDouglas B Evans
Aug 27, 2009·Annals of Surgical Oncology·Giuliano BarugolaMassimo Falconi
Oct 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip A PhilipJoel Tepper
Jan 27, 2010·Nature Reviews. Clinical Oncology·Anastasios Stathis, Malcolm J Moore
May 19, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Michael HaasStefan Boeck
Jan 10, 2012·Cancer Treatment Reviews·Volker HeinemannStefan Boeck
Sep 22, 2012·International Journal of Clinical Oncology·Faruk TasIbrahım Yıldız
Nov 1, 2012·Gut·Patrick Michl, Thomas M Gress
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Apr 3, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hideki UenoMasao Tanaka
Oct 18, 2013·The New England Journal of Medicine·Daniel D Von HoffMarkus F Renschler

❮ Previous
Next ❯

Citations

Jan 16, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Nha LeUNKNOWN GEMS collaborating group of Pancreas 2000
Mar 5, 2016·Cancer Chemotherapy and Pharmacology·Thierry WendlingLeon Aarons
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sven H LoosenTom Luedde
May 16, 2020·Clinics and Research in Hepatology and Gastroenterology·Lola-Jade PalmieriSolène Doat
Jan 7, 2019·Seminars in Oncology·Si Shi, Xianjun Yu

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
surgical
biopsy

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.