PMID: 12752098May 20, 2003Paper

A prognostic model for survival in chronic lymphocytic leukaemia based on p53 expression

British Journal of Haematology
Francis J GilesM Albitar

Abstract

As the abnormal expression of p53 protein is prognostically significant in some human cancers, its significance in patients with B-cell chronic lymphocytic leukaemia (CLL) was assessed. Two investigators evaluated the percentage of bone marrow mononuclear cells that stained for p53, using biopsies stained with anti-p53 monoclonal antibody (DO-7), and graded the degree of staining (0, +, ++, +++). Samples from a cohort of 90 patients with CLL were studied (median age 60 years, range 30-89 years; 57 patients were (63%) previously untreated, 22 patients (24%) had received one or two prior regimens, 11 patients had received (12%) three to seven regimens. The overall percentage of cells positive for p53 staining was a median of 43 (range 1-88). No investigator effect was detected either in overall percentage cells rated p53 positive or on the degree of staining (Pearson's correlation coefficient 0.980, P-value < 0.001). A Cox proportional hazards model showed that the percentage of ++ and +++ p53-positive cells correlated with various prognostic factors in CLL (P < 0.0001). A multivariate model incorporating prior therapy, Rai stage, beta2 microglobulin (beta2M) and p53 expression showed that only the percentage of p53-positive cell...Continue Reading

References

Jul 2, 1992·Nature·D P Lane
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G GaidanoR Dalla-Favera
Jan 1, 1995·Cancer Treatment and Research·P M Grambsch
Dec 1, 1994·British Journal of Haematology·D GandiniL del Senno
Aug 15, 1994·International Journal of Cancer. Journal International Du Cancer·M Aguilar-SantelisesM Jondal
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S M O'BrienM Keating
Feb 8, 2002·The New England Journal of Medicine·Ian F PollackUNKNOWN Children's Cancer Group
Mar 20, 2002·Nature Reviews. Cancer·A N Bullock, A R Fersht
Apr 19, 2002·Biochimica Et Biophysica Acta·Karen H Vousden
Jun 12, 2002·Current Treatment Options in Oncology·J H Ward

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Citations

Mar 11, 2004·Mayo Clinic Proceedings·Tait D Shanafelt, Timothy G Call
Dec 22, 2009·American Journal of Clinical Pathology·Hong ChangConnie X Y Qi
Mar 18, 2008·Best Practice & Research. Clinical Haematology·Elihu H Estey
Nov 18, 2003·British Journal of Haematology·Julio Delgado, Maria Cristina Fernandez-Jimenez
Nov 22, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Arjen H G ClevenRobert P Hasserjian
Feb 6, 2004·Hematological Oncology
Aug 1, 2020·The Cochrane Database of Systematic Reviews·Nina KreuzbergerNicole Skoetz

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