A prognostic model predicts the risk of distant metastasis and death for patients with nasopharyngeal carcinoma based on pre-treatment interleukin 6 and clinical stage

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Liangru KeXing Lv

Abstract

Because inflammation plays a critical role in nasopharyngeal carcinoma (NPC), this study aims to investigate the correlation between the pro-inflammation cytokine interleukin-6 (IL6) and the prognosis of NPC and develop a new prognostic model. IL6 levels were measured in the serum of 290 NPC patients by ELISA and the correlation between IL6 and prognosis of NPC was evaluated by Kaplan-Meier analysis and multivariate analysis. The results showed that elevated IL6 levels were positively correlated with poorer 9-year overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS) and lung metastasis-free survival (lung-MFS). IL6 level was an independent prognostic factor for OS, DFS, DMFS and lung-MFS. The CI-model based on TNM stage and IL6 level could better predict the OS, DFS, DMFS and lung-MFS of NPC patients. Here, the newly developed prognostic CI-model for predicting distant metastasis and death of NPC patients could facilitate patients consulting and individualized immunotherapy.

References

Apr 1, 1991·American Journal of Obstetrics and Gynecology·J S BerekO Martínez-Maza
Aug 1, 1997·The Journal of Infectious Diseases·T van der PollS F Lowry
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Al-SarrafJ F Ensley
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Mar 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Anne W M LeeW H Lau
Apr 28, 2005·Virchows Archiv : an International Journal of Pathology·Xavier DolcetXavier Matias-Guiu
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne W M LeeUNKNOWN Hong Kong Nasopharyngeal Cancer Study Group
Dec 22, 2007·Nature Reviews. Immunology·Laurence ZitvogelGuido Kroemer
Nov 15, 2008·Annual Review of Immunology·Michael Dougan, Glenn Dranoff
Mar 13, 2009·Nature Reviews. Cancer·Johanna A Joyce, Jeffrey W Pollard
Jul 1, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy LeeK Kian Ang
Apr 30, 2010·Chinese Journal of Cancer·Joseph Tien Seng WeeChao-Nan Qian
Jan 29, 2011·Chinese Journal of Cancer·Su-Mei CaoChao-Nan Qian
Oct 1, 2011·Journal of Cancer Research and Clinical Oncology·Qianjin LiaoGuiyuan Li
Apr 11, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Wei-Xiong XiaYan-Qun Xiang
Mar 20, 2014·The Journal of Clinical Investigation·Matjaz RokavecHeiko Hermeking
Aug 8, 2014·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Reinhild HolmerHolger Kalthoff
Sep 17, 2014·Clinical & Experimental Metastasis·Yu ZhengMarkus J Seibel
Oct 10, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Samia A AhmedOmar S Omar

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Citations

Aug 9, 2016·Journal of Biochemical and Molecular Toxicology·Hong-Ling YanWei Xu
May 1, 2019·The Cochrane Database of Systematic Reviews·Daniel Molano FrancoJavier Zamora
Mar 16, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Masayuki AkitaYonson Ku
Apr 11, 2020·Scientific Reports·Hui Min LeeLee Fah Yap

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