A program against bacterial bioterrorism: improved patient management and acquisition of new knowledge on infectious diseases

Biosecurity and Bioterrorism : Biodefense Strategy, Practice, and Science
Michael KempJens Jørgen E Christensen

Abstract

In 2002 it was decided to establish laboratory facilities in Denmark for diagnosing agents associated with bioterrorism in order to make an immediate appropriate response to the release of such agents possible. Molecular assays for detection of specific agents and molecular and proteomic techniques for identification of bacteria were introduced as part of the program. All assays and techniques were made accessible for use in diagnosing patients, even when an intentional release was not suspected. Medical expertise on different diseases was established at the department as an integrated part of the program. The analyses included PCR assays for specific bacteria, identification of isolated bacteria by DNA sequencing, detection and identification of bacteria in clinical sample material by universal bacterial PCR and DNA sequencing, and identification of bacteria by mass spectrometry. The established analyses formed a basis on which a series of further developments was built. In addition to reducing the time for obtaining diagnoses and improving the accuracy of diagnosis of individual infected patients, the analyses provided new knowledge on the frequency and distribution of some bacterial infections, including Q fever, tularemia, ...Continue Reading

References

Oct 7, 2005·Journal of Clinical Microbiology·Mark ReinhardJens Jørgen Christensen
Oct 13, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jens Jørgen ChristensenMichael Kemp
Feb 3, 2007·Journal of Clinical Microbiology·Ulrik S JustesenJens J Christensen
Apr 25, 2007·Scandinavian Journal of Infectious Diseases·Marie BoennelyckeSøren Krause
Jul 27, 2007·Scandinavian Journal of Infectious Diseases·Rawaa Jalil Abdul-RedhaMichael Kemp
Aug 19, 2007·Scandinavian Journal of Infectious Diseases·Rawaa Jalil Abdul-RedhaJens Jørgen Christensen
Nov 26, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ann Sofie GleesenMichael Kemp
Dec 17, 2008·Scandinavian Journal of Infectious Diseases·Kristina IblerJens Jørgen Christensen
Dec 18, 2008·The Open Microbiology Journal·Helle HolstJens Jørgen Christensen
Dec 18, 2008·The Open Microbiology Journal·Claus MoserJens Jørgen Christensen
Aug 7, 2009·The Open Microbiology Journal·J M HansenJ J Christensen
Mar 6, 2010·Emerging Infectious Diseases·Anders KochSteen Villumsen
Mar 20, 2010·Scandinavian Journal of Infectious Diseases·Shadia BadranJens Jørgen Christensen
May 1, 2010·Scandinavian Journal of Infectious Diseases·Gitte Nyvang HartmeyerJens Jørgen E Christensen
Jul 17, 2010·Future Microbiology·Michael KempJens Jørgen Christensen
Jan 1, 2010·The Open Biomedical Engineering Journal·Jeffrey J HeysHari P Chaliki

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Methods Mentioned

BETA
PCR

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