PMID: 3753778Jan 10, 1986Paper

A program for the identification of tRNA-like structures in DNA sequence data

Nucleic Acids Research
C C Marvel

Abstract

A computer algorithm has been developed which identifies tRNA genes and tRNA-like structures in DNA sequences. The program searches the sequence string for specific base positions that correspond to the invariant and semi-invariant bases found in tRNAs. The tRNA nature of the sequence is confirmed by the presence of complementary base pairing at the tRNA's calculated 5' and 3' ends (which in situ constitutes the amino-acyl stem region). The program achieves greater than 96% accuracy when run against known tRNA sequences in the Genbank database. The program is modular and is readily modified to allow searching either a file or database. The program is written in "C" and operates on a D.E.C. Vax 750. The utility of the algorithm is demonstrated by the identification of a distinctive tRNA structure in an intron of a published bovine hemoglobin gene.

References

Feb 10, 1984·Nucleic Acids Research·J C Schimenti, C H Duncan
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B N AmesM F Christman

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Citations

Aug 5, 1991·Journal of Molecular Biology·G A Fichant, C Burks
Jan 1, 1995·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·J SunR S Chen
Jan 1, 1995·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·M S Gelfand
Dec 23, 1987·Nucleic Acids Research·C R ZelnickC H Duncan
Jun 11, 1994·Nucleic Acids Research·S R Eddy, R Durbin
Nov 25, 1994·Nucleic Acids Research·Y SakakibaraD Haussler
Oct 9, 2012·Biochimica Et Biophysica Acta·Giorgio DieciDavide Carnevali
Jan 1, 1990·American Journal of Industrial Medicine·J J May

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