A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates

Nature Chemistry
Penghui ZhangWeihong Tan

Abstract

Stimuli-responsive biomaterials that contain logic gates hold great potential for detecting and responding to pathological markers as part of clinical therapies. However, a major barrier is the lack of a generalized system that can be used to easily assemble different ligand-responsive units to form programmable nanodevices for advanced biocomputation. Here we develop a programmable polymer library by including responsive units in building blocks with similar structure and reactivity. Using these polymers, we have developed a series of smart nanocarriers with hierarchical structures containing logic gates linked to self-immolative motifs. Designed with disease biomarkers as inputs, our logic devices showed site-specific release of multiple therapeutics (including kinase inhibitors, drugs and short interfering RNA) in vitro and in vivo. We expect that this 'plug and play' platform will be expanded towards smart biomaterial engineering for therapeutic delivery, precision medicine, tissue engineering and stem cell therapy.

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Citations

Jun 17, 2020·Journal of Biophotonics·Eran A BarnoyDror Fixler
Sep 30, 2020·Chemical Communications : Chem Comm·Xiong LiuDidier Astruc
Sep 5, 2020·Pharmaceutics·Shi Su, Peter M Kang
Sep 22, 2020·Angewandte Chemie·Ayan ChatterjeeDibyendu Das
Feb 12, 2021·Nature Communications·Zhongyu LiLiangliang Zhu
Feb 10, 2021·Angewandte Chemie·Miao SunChaoyong Yang
Apr 22, 2021·Biomedical Materials·Mengjiao ZhouHaijun Yu
Jun 15, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaowei LuanYujun Song
Jul 13, 2021·Frontiers in Bioengineering and Biotechnology·Di ChangShenghong Ju
Jul 15, 2021·Advanced Science·Shasha LuXiurong Yang
Jan 19, 2021·ACS Biomaterials Science & Engineering·Yuhang HuangMatthew G Moffitt
Aug 20, 2021·Chembiochem : a European Journal of Chemical Biology·Lujia HuangHaijun Yu
Sep 18, 2021·ACS Applied Materials & Interfaces·Bijiang GengLongxiang Shen
Oct 4, 2021·Advanced Materials·Yue ZhangChao Wang
Nov 2, 2021·Nano Letters·Xiangang HuangWei Tao

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Methods Mentioned

BETA
biosensing
fluorescence-activated cell sorting
xenograft
fluorescence imaging
fluorescence

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