A proliferative effect of transforming growth factor-beta1 on a human prostate cancer cell line, TSU-Pr1

Endocrinology
M L LammC Lee

Abstract

Transforming growth factor -beta (TGF-beta) is growth inhibitory to many malignant cells, including prostate cancer cells. The present study reports an unusual observation in that TGF-beta is growth stimulatory to a human prostate cancer cell line, TSU-Pr1. The TSU-Pr1 line is highly aggressive and exhibits a rapid rate of proliferation in culture. These cells underwent further proliferation in response to TGF-beta1. Both type I and II receptors to TGF-beta (TPR-I, TPR-II) are expressed in TSU-Pr1 cells. Activation of a luciferase reporter gene, which contains a TGF-beta response element, confirmed that the TGF-beta receptors in TSU-Pr1 cells were functional. RT-PCR analysis and an ELISA assay determined that TSU-Pr1 cells secreted TGF-beta. In conclusion, TSU-Pr1 cells contain functional TGF-beta receptors but instead of the usual growth inhibition by TGF-beta1, these cells undergo proliferation. The present observation provides a proliferative role of TGF-beta in TSU-Pr1 cells, which may play a part in the aggressive phenotype of these cells and, perhaps other prostate cancer cells.

Citations

Nov 7, 2001·The American Journal of Pathology·J LawlerR O Hynes
Sep 6, 2000·Journal of Clinical Pharmacy and Therapeutics·D KajdaniukT Wielkoszyski
Feb 13, 2001·Journal of Cellular Physiology·B Pasche
Oct 21, 2004·Cancer·David G BostwickBarry Timms
Apr 15, 2004·Endocrine Reviews·Cynthia A Heinlein, Chawnshang Chang
Jun 17, 2014·International Journal of Cancer. Journal International Du Cancer·Xin LiJin-Tang Dong
May 27, 1999·The Prostate·C LeeJ A Sensibar

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