PMID: 9557699Apr 29, 1998Paper

A proline-rich motif (PPPY) in the Gag polyprotein of Mason-Pfizer monkey virus plays a maturation-independent role in virion release

Journal of Virology
J Yasuda, E Hunter

Abstract

Virus assembly represents one of the last steps in the retrovirus life cycle. During this process, Gag polyproteins assemble at specific sites within the cell to form viral capsids and induce membrane extrusion (viral budding) either as assembly progresses (type C virus) or following formation of a complete capsid (type B and type D viruses). Finally, the membrane must undergo a fusion event to pinch off the particle in order to release a complete enveloped virion. Structural elements within the MA region of the Gag polyprotein define the route taken to the plasma membrane and direct the process of virus budding. Results presented here suggest that a distinct region of Gag is necessary for virus release. The pp24 and pp16 proteins of the type D retrovirus Mason-Pfizer monkey virus (M-PMV) are phosphoproteins that are encoded in the gag gene of the virus. The pp16 protein is a C-terminally located cleavage product of pp24 and contains a proline-rich motif (PPPY) that is conserved among the Gag proteins of a wide variety of retroviruses. By performing a functional analysis of this coding region with deletion mutants, we have shown that the pp16 protein is dispensable for capsid assembly but essential for virion release. Moreover,...Continue Reading

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Citations

Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·A PatnaikJ W Wills
Jan 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dimiter G DemirovEric O Freed
Jun 7, 2002·Journal of Virology·Fatima SerhanGhislaine Duisit
Oct 29, 2003·Journal of Virology·Juan Martin-Serrano, Paul D Bieniasz
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Eiji Morita, Wesley I Sundquist
Mar 31, 2006·Journal of Virology·Shuzo UrataJiro Yasuda
Jul 12, 2008·Reviews in Medical Virology·A CalistriG Palù
Jun 17, 2014·Microbiology and Immunology·Masumi AbeJiro Yasuda
Jan 31, 2002·AIDS·H G Göttlinger
Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·S D Parker, E Hunter
Mar 29, 2003·Journal of Virology·Juan Martin-SerranoPaul D Bieniasz
Jul 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Manuela MuraMassimo Palmarini
Mar 18, 2004·Reviews in Medical Virology·Catherine S Adamson, Ian M Jones
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·B StrackH G Gottlinger
Aug 28, 2003·Journal of Virology·Jiro YasudaHisatoshi Shida
Dec 9, 2003·Journal of Biology·Margaret Q WangStephen P Goff
Mar 1, 2003·Journal of Virology·David E OttUlrich Schubert
Mar 25, 2006·Uirusu·Jiro Yasuda
Jul 21, 2015·Microbiology and Immunology·Chisato Narahara, Jiro Yasuda
Sep 5, 2002·Journal of Virology·Isabelle Le BlancArielle R Rosenberg

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