A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice

The Journal of Pain : Official Journal of the American Pain Society
N GaleottiC Ghelardini

Abstract

The antinociceptive profile of St. John's Wort (SJW) was investigated in mice in a condition of acute thermal and chemical pain, together with the mechanism that might underlie this effect. A dried extract of SJW induced a prolonged antinociception that persisted for 120 minutes after administration. The thermal antinociception was prevented by naloxone and by the protein kinase C (PKC) activator PMA, whereas the chemical antinociception was prevented by PMA, remaining naloxone insensitive. A chloroform (CHL) and a methanol (MET) fraction, obtained to investigate the involvement of the SJW main components, hyperforin and hypericin/flavonoid, respectively, increased pain threshold with a time course comparable to the dried extract. The CHL antinociception was prevented by naloxone, whereas the MET antinociception was antagonized by PMA. Purified hyperforin and hypericin showed an antinociceptive efficacy comparable to CHL and MET, respectively. Conversely, flavonoids were devoid of any effect. The administration of yohimbine and atropine did not modify SJW, CHL and MET antinociception. These results indicate that both CHL and MET fractions mediate the SJW-induced antinociception. In particular, the presence of hypericin was fund...Continue Reading

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Citations

Oct 19, 2010·Journal of Natural Medicines·Celia Xiomara BonkankaRosa María Rabanal
Aug 15, 2014·The Journal of Pharmacy and Pharmacology·Eveline Dischkaln StolzStela M K Rates
May 23, 2012·Expert Opinion on Drug Metabolism & Toxicology·Roja Rahimi, Mohammad Abdollahi
Apr 13, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·N Galeotti, C Ghelardini
Oct 1, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Maria Domenica SannaNicoletta Galeotti
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