A Promising Emodin-Loaded Poly (Lactic-Co-Glycolic Acid)-d-α-Tocopheryl Polyethylene Glycol 1000 Succinate Nanoparticles for Liver Cancer Therapy

Pharmaceutical Research
Hongyan LiuYan Tian

Abstract

Emodin (EMO) has multi-targets and multi-way antitumor effect, which was limited by the instability and poor solubility of EMO. The aim of this study was to formulate EMO-loaded poly (lactide-co-glycolide)-d-α-tocopheryl polyethylene glycol 1000 succinate (PLGA-TPGS) nanoparticles (EPTN) to increase the liver targeting of EMO for cancer therapy. EMO/coumarin-6-loaded PLGA-TPGS nanoparticles (ECPTN) and EMO-loaded PLGA nanoparticles (EPN) were also prepared as comparison. The cellular uptake of ECPTN by HepG2 and HCa-F cells was investigated using Confocal laser scanning microscopy. The apoptosis of HepG2 cells handled with EPTN was assayed by flow cytometry. The liver targeting property of ECPTN in mice was evaluated using the drug concentration determined by RP-HPLC and the freezing slices were investigated via fluorescence inversion microscopy. The blood samples were obtained from vein intubation to illustrate the pharmacokinetics process of EPTN. The tumor-bearing mice model was established to elucidate the in vivo therapeutic effect of EPTN. The results demonstrated that ECPTN could be internalized by HepG2 and HCa-F cells respectively. The ratio of apoptosis cells was increased after dealing with EPTN. The detection indexe...Continue Reading

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Citations

Oct 8, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Weipeng WeiFushan Tang
Nov 22, 2017·Journal of Drug Targeting·Md RizwanullahMohd Moshahid Alam Rizvi
Mar 17, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Hardeep Singh TuliKatrin Sak
Jun 3, 2021·Cancers·Esra Küpeli AkkolRaffaele Capasso
Aug 30, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Keenan J Mintz, Roger M Leblanc

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