A Promoter Polymorphism of the Vitamin D Metabolism Gene Cyp24a1 is Associated with Severe Atopic Dermatitis in Adults

Acta Dermato-venereologica
Jana HallauGuido Heine

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease in which genetic and environmental factors result in impaired epidermal barrier functioning and an altered immune response. Vitamin D influences these 2 pathomechanisms, and beneficial results have been suggested in AD. The aim of this study was to investigate the potential roles of the 2 essential vitamin D metabolizing enzymes. The frequencies of 6 common polymorphisms in the genes encoding the vitamin D synthesizing enzyme Cyp27b1 or the inactivating enzyme Cyp24a1 were assessed in 281 patients with AD and 278 healthy donors in a case-control setting. The Cyp24a1 rs2248359-major C allele was significantly over-represented in patients with AD compared with controls, which was more pronounced in patients with severe AD. In addition, haplotypes of the Cyp24a1 and Cyp27b1 genes were associated with AD. These data support that vitamin D mediates beneficial functions in AD and suggest that future studies on the impact of vitamin D on AD should consider the individual genotypes of the vitamin D metabolizing enzymes.

Citations

Mar 26, 2016·Expert Review of Clinical Immunology·Shannon K QuirkDevendra K Agrawal
Aug 3, 2016·International Journal of Molecular Sciences·Jung Eun KimHyun Jeong Park
Sep 21, 2016·International Journal of Molecular Sciences·Yu Ri WooHyun Jeong Park
Jul 12, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S Pérez-PérezR Álvarez-Lafuente
Jan 8, 2018·Skin Pharmacology and Physiology·Meenakshi UmarAouatef I Chouchane
Mar 11, 2021·Dermatology Research and Practice·Siavash RahimiSeyedeh Sareh Shafaei-Tonekaboni

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