A propagating heat wave model of skin electroporation

Journal of Theoretical Biology
U PliquettRichard Nuccitelli

Abstract

The main barrier to transdermal drug delivery in human skin is the stratum corneum. Pulsed electric fields (PEFs) of sufficient amplitude can create new aqueous pathways across this barrier and enhance drug delivery through the skin. Here, we describe a model of pore formation between adjacent corneocytes that predicts the following sequence of events: (1) the PEF rapidly charges the stratum corneum near the electrode until the transepidermal potential difference is large enough to drive water into a small region of the stratum corneum, creating new aqueous pathways. (2) PEFs then drive a high current density through this newly created electropore to generate Joule heating that warms the pore perimeter. (3) This temperature rise at the perimeter increases the probability of further electroporation there as the local sphingolipids reach their phase transition temperature. (4) This heat-generated wave of further electroporation propagates outward until the surface area of the pore becomes so large that the reduced current density no longer generates sufficient heat to reach the phase transition temperature of the sphingolipids. (5) Cooling and partial recovery occurs after the field pulse. This process yields large, high permeabi...Continue Reading

References

May 24, 1988·Biochimica Et Biophysica Acta·R W GlaserA I Sokirko
Nov 1, 1995·Biochimica Et Biophysica Acta·U PliquettJ C Weaver
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M R PrausnitzJ C Weaver
Dec 1, 1996·Journal of Pharmaceutical Sciences·M R PrausnitzC Cullander
Jun 17, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·R VanbeverJ C Weaver
May 3, 2000·Bioelectrochemistry·U F Pliquett, C A Gusbeth
Jun 6, 2000·Advanced Drug Delivery Reviews·J C WeaverY Chizmadzhev
Jun 7, 2002·Bioelectrochemistry·Gregory T MartinJames C Weaver

❮ Previous
Next ❯

Citations

Mar 22, 2016·Pharmaceutics·Kevin Ita
Oct 1, 2013·International Journal of Pharmaceutics·Barbara ZorecNataša Pavšelj
Jul 16, 2014·Mathematical Biosciences·Sid BeckerNataša Pavšelj
Mar 21, 2020·Expert Opinion on Drug Delivery·Janja Dermol-ČerneDamijan Miklavčič

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.