A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine

Nutrients
Vibeke AndersenTorkell Ellingsen

Abstract

Chronic inflammatory diseases (CIDs), including Crohn's disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors). Approximately one-third of the patients do not respond to the treatment. Genetics and lifestyle may affect the treatment results. The aims of this multidisciplinary collaboration are to identify (1) molecular signatures of prognostic value to help tailor treatment decisions to an individual likely to initiate TNF inhibitor therapy, followed by (2) lifestyle factors that support achievement of optimised treatment outcome. This report describes the establishment of a cohort that aims to obtain this information. Clinical data including lifestyle and treatment response and biological specimens (blood, faeces, urine, and, in IBD patients, intestinal biopsies) are sampled prior to and while on TNF inhibitor therapy. Both hypothesis-driven and data-driven analyses will be performed according to pre-specified protocols including pathway analyses resulting from candida...Continue Reading

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Citations

Nov 18, 2018·Journal of Digestive Diseases·Yi Quan ZhouYan Ping Wan
Feb 23, 2020·Expert Review of Gastroenterology & Hepatology·Charlene Sj GrosseIan C Lawrance
Jul 12, 2019·AIMS Microbiology·Ellie SayersSimon R Carding
Dec 18, 2020·Frontiers in Immunology·Tobias J DemetrowitschSilvio Waschina
Aug 3, 2021·Frontiers in Pharmacology·Linshan DuanGuoyan Liu

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Methods Mentioned

BETA
biopsies
glycosylation
genotyping

Software Mentioned

GTEx
SIFT
DANN
HaploReg
DEPICT

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