A proposal for pathologic processing of breast implant capsules in patients with suspected breast implant anaplastic large cell lymphoma.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Kirill A LyapichevRoberto N Miranda

Abstract

Breast implant anaplastic large cell lymphoma is an entity recently recognized by the World Health Organization. The tumor arises around textured-surface breast implants and is usually confined to the surrounding fibrous capsule. Currently, there are no recommendations for handling and sampling of capsules from patients with suspected breast implant anaplastic large cell lymphoma without a grossly identifiable tumor. We analyzed complete capsulectomies without distinct gross lesions from patients with breast implant anaplastic large cell lymphoma. The gross appearance of the capsules as well as the presence, extent and depth of tumor cells on the luminal side and number of sections involved by lymphoma were determined by review of routine stains and CD30 immunohistochemistry. We then used a mathematical model that included the extent of tumor cells and number of positive sections to calculate the minimum number of sections required to identify 95% of randomly distributed lesions. We identified 50 patients with breast implant anaplastic large cell lymphoma who had complete capsulectomies. The implants were textured in all 32 (100%) cases with available information. Anaplastic large cell lymphoma was found in 44/50 (88%) capsules...Continue Reading

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Citations

Mar 10, 2021·American Journal of Clinical Pathology·Catalina Amador, Andrew L Feldman
Mar 26, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Antonella CampanaleLucia Lispi
Apr 24, 2021·Plastic and Reconstructive Surgery·Maurice Y Nahabedian
Jun 23, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mark G EvansRoberto N Miranda
May 29, 2021·Aesthetic Surgery Journal·Roberto N Miranda, Mario L Marques-Piubelli

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Methods Mentioned

BETA
flow cytometry

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